Handbook of Imaging in Multiple Sclerosis

Dejan Jakimovski, MD, Ph.D., is a Research Assistant Professor at the Department of Neurology, University at Buffalo, the State University of New York and Clinical Research Unit Director at Buffalo Neuroimaging Analysis Center. In 2015, Dr. Jakimovski received his medical degree at Ss. Cyril and Methodius University, Skopje, Macedonia and in 2020 he also received Neuroscience Ph.D. degree at University at Buffalo. He performed research spanning from cardiovascular, environmental and genetic risk factors in multiple sclerosis (MS) and use of quantitative multimodal imaging techniques in predicting disease outcomes in MS and other neurodegenerative diseases. Furthermore, his focus included clinical, neuropsychological and optical coherence tomography (OCT) characterization of both adult and aging MS populations. Robert Zivadinov, MD, Ph.D., has served as Director of the Buffalo Neuroimaging Analysis Center (BNAC) since 2003. The Center is part of the Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York, where he is Professor of Neurology. He also is Director of the University’s Center for Biomedical Imaging at the Clinical Translational Science Institute.Having published more than 450 articles and 750 abstracts in leading peer-reviewed journals, Dr. Zivadinov’s work is widely cited with H-index of 80.He is Honorary Professor of Neurology at the University of Sidney, Australia. Dr. Zivadinov was a founding member of the International Society for Neurovascular Disease and currently serves on its Executive Committee.

• Section 1: Introduction1. Immunology and Pathophysiology of Multiple Sclerosis2. Diagnosis and Clinical Features of Multiple Sclerosis3. Cognition in Multiple Sclerosis4. Multiple Sclerosis Treatment5. Use of MRI and Quantitative MRI Reports in Clinical Care of Multiple Sclerosis6. MRI Outcomes in MS Clinical TrialsSection 2: Imaging of Multiple Sclerosis7. Conventional MRI use in Multiple Sclerosis8. MRI Physics and Image Acquisition9. Basics of Neuroimaging Analysis10. Lesions Imaging in Multiple Sclerosis11. Volumetry and Atrophy in Multiple Sclerosis12. Spinal Cord Imaging in Multiple SclerosisSection 3: Non-conventional MRI use in Multiple Sclerosis13. Diffusion Tensor Imaging in Multiple Sclerosis14. Magnetization Transfer Imaging in Multiple Sclerosis15. Susceptibility-Weighted Imaging in Multiple Sclerosis16. Quantitative Susceptibility Mapping in Multiple Sclerosis17. Functional MRI imaging in Multiple Sclerosis18. Perfusion-Weighted Imaging in Multiple Sclerosis19. Magnetic Resonance Spectroscopy in Multiple Sclerosis20. High-Field Imaging in Multiple Sclerosis21. Emerging MRI BiomarkersSection 4: Use of Other Imaging Acquisition and Analysis Modalities in Multiple Sclerosis22. Positron Emission Tomography in Multiple Sclerosis23. Optical Coherence Tomography in Multiple Sclerosis - Elliot M Frohman24. Imaging of Multiple Sclerosis in Resource-Poor Settings25. Use of Artificial Intelligence in Multiple Sclerosis Imaging26. Imaging of Experimental Models of Multiple Sclerosis