Handbook for DNA-Encoded Chemistry

Theory and Applications for Exploring Chemical Space and Drug Discovery

Inbunden, Engelska, 2014

Av Robert A. Goodnow, Jr. Goodnow, Robert A., Robert A Goodnow

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This book comprehensively describes the development and practice of DNA-encoded library synthesis technology.Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book: Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistryHelps chemists generate and screen novel chemical libraries of large size and qualityBridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistryShows medicinal and pharmaceutical chemists how to efficiently broaden available "chemical space" for drug discoveryProvides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods

Produktinformation

Utgivningsdatum2014-08-08
Mått160 x 241 x 31 mm
Vikt807 g
FormatInbunden
SpråkEngelska
Antal sidor480
FörlagJohn Wiley & Sons Inc
ISBN9781118487686

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ROBERT A. GOODNOW, JR. is the Executive Director of the Chemistry Innovation Centre, Discovery Sciences at AstraZeneca and the Founder of GoodChem Consulting, LLC. He has extensive experience in drug discovery and chemistry technologies including carbohydrate, combinatorial, oligonucleotide, and analytical chemistry. Robert Goodnow has authored or coauthored nearly 100 publications and patents and has spoken extensively on the topics of drug lead finding and the outsourcing of drug discovery chemistry. He has lectured as an adjunct professor of medicinal chemistry.

Preface viiAcknowledgments ixIntroductory Comments xiContributors xxiii1 Just enough knowledge… 1Agnieszka Kowalczyk2 A brief history of the development of combinatorial chemistry and the emerging need for DNA-encoded chemistry 19Robert A. Goodnow, Jr.3 A brief history of DNA-encoded chemistry 45Anthony D. Keefe4 DNA-Compatible Chemistry 67Kin-Chun Luk and Alexander Lee Satz5 Foundations of a DNA-encoded library (DEL) 99Alexander Lee Satz6 Exercises in the Synthesis of DNA-encoded Libraries 123Steffen P. Creaser and Raksha A. Acharya7 The DNA Tag: A Chemical gene designed for DNA-encoded libraries 153Andrew W. Fraley8 Analytical challenges for DNA-encoded library systems 171George L. Perkins and G. John Langley9 Informatics: Functionality and architecture for DNA-encoded library production and screening 201John A. Feinberg and Zhengwei Peng10 Theoretical considerations of the application of DNA-encoded libraries to drug discovery 213Charles Wartchow11 Begin with the End in Mind: The hit-to-lead process 231John Proudfoot12 Enumeration and Visualization of Large Combinatorial Chemical Libraries 247Sung-Sau So13 Screening Large Compound Collections 281Stephen P. Hale14 Reported applications of DNA-encoded library chemistry 319Johannes Ottl15 Dual-Pharmacophore DNA-encoded Chemical Libraries 349Jörg Scheuermann and Dario Neri16 Hit Identification and Hit Follow-up 357Yixin Zhang17 Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding 377Lynn M. McGregor and David R. Liu18 The changing feasibility and economics of chemical diversity exploration with DNA-encoded combinatorial approaches 417Robert A. Goodnow, Jr.19 Keeping the promise? An outlook on DNA chemical library technology 427Samu Melkko and Johannes OttlIndex 435