Genomics, Proteomics and Metabolomics in Nutraceuticals and Functional Foods

Debasis Bagchi, Ph.D., MACN, CNS, MAIChEUniversity of Houston College of Pharmacy, Houston, TX, USAAnand Swaroop, Ph.D.Cepham Inc., Piscataway, NJ, USAManashi Bagchi, Ph.D., FACNCepham Inc., Piscataway, NJ, USA

• Contributors xxivPreface xxxiPart I Introduction 11 Novel Omics Technologies in Food Nutrition 3Xuewu Zhang, Lijun You, Wei Wang, and Kaijun Xiao2 Seafood Authentication using Foodomics: Proteomics, Metabolomics, and Genomics 14Karola Böhme, Jorge Barros-Velázquez, Pilar Calo-Mata, José M. Gallardo, and Ignacio Ortea3 A Foodomics Approach Reveals Hypocholesterolemic Activity of Red Microalgae 31Irit Dvir, Aliza H. Stark, and Shoshana (Malis) AradPart II Genomics 414 Gene-Diet Interaction and Weight Management 43Lu Qi5 NutrimiRomics: The Promise of a New Discipline in Nutrigenomics 53Amitava Das and Chandan K. Sen6 Genomics as a Tool to Characterize Anti-inflammatory Nutraceuticals 61Amitava Das, Scott Chaffee, and Sashwati Roy7 Nutrigenomics, Inflammaging, and Osteoarthritis: A Review 71Ali Mobasheri, Richard Barrett-Jolley, Caroline A. Staunton, Chris Ford, and Yves Henrotin8 Genetic Basis of Anti-Inflammatory Properties of Boswellia Extracts 85Golakoti Trimurtulu, Chandan K. Sen, Alluri V. Krishnaraju, Kiran Bhupathiraju, and Krishanu Sengupta9 Cancer Chemopreventive Phytochemicals Targeting NF-κB and Nrf2 Signaling Pathways 102Hye-Kyung Na and Young-Joon Surh10 The Beneficial Health Effects of Fucoxanthin 122Kazuo Miyashita and Masashi Hosokawa11 Nutrition, Genomics, and Human Health: A Complex Mechanism for Wellness 135Okezie I. Aruoma12 Application of Genomics and Bioinformatics Analysis in Exploratory Study of Functional Foods 140Kohsuke Hayamizu and Aiko Manji13 Omics Analysis and Databases for Plant Science 150Masaaki Kobayashi, Hajime Ohyanagi, and Kentaro Yano14 Synergistic Plant Genomics and Molecular Breeding Approaches for Ensuring Food Security 160Shouvik Das and Swarup K. Parida15 Combinatorial Approaches Utilizing Nutraceuticals in Cancer Chemoprevention and Therapy: A Complementary Shift with Promising Acuity 185Madhulika Singh and Yogeshwer Shukla16 Nutrigenomic Approaches to Understanding the Transcriptional and Metabolic Responses of Phytochemicals to Diet-Induced Obesity and its Complications 218Myung-Sook Choi and Eun-Young Kwon17 Going Beyond the Current Native Nutritional Food Through the Integration of the Omic Data in the Post-Genomic Era: A Study in (Resistant) Starch Systems Biology 230Treenut Saithong and Saowalak KalapanulakPart III Proteomics 24318 Proteomics and Nutrition Research: An Overview 245Arun K. Tewari, Sudhasri Mohanty, and Sashwati Roy19 Proteomics Analysis for the Functionality of Toona sinensis 253Sue-Joan Chang and Chun-Yung Huang20 Proteomic Approaches to Identify Novel Therapeutics and Nutraceuticals from Filamentous Fungi: Prospects and Challenges 265Samudra Prosad Banik, Suman Khowala, Chiranjib Pal, and Soumya Mukherjee21 Proteomics and Metaproteomics for Studying Probiotic Activity 296Rosa Anna Siciliano and Maria Fiorella Mazzeo22 Proteomics Approach to Assess the Potency of Dietary Grape Seed Proanthocyanidins and Dimeric Procyanidin B2 304Hai-qing Gao, Bao-ying Li, Mei Cheng, Xiao-li Li, Fei Yu, and Zhen Zhang23 Genomic and Proteomic Approaches to Lung Transplantation: Identifying Relevant Biomarkers to Improve Surgical Outcome 321John Noel, Ronald Carnemola, and Shampa Chatterjee24 Proteomics in Understanding the Molecular Basis of Phytochemicals for Health 328Jung Yeon Kwon, Sanguine Byun, and Ki Won Lee25 Genomics/Proteomics of NEXT-II, a Novel Water-Soluble, Undenatured Type II Collagen in Joint Health Care 338Orie Yoshinari, Hiroyoshi Moriyama, Manashi Bagchi, and Debasis BagchiPart IV Metabolomics 34726 Harnessing Metabolic Diversity for Nutraceutical Plant Breeding 349Ashish Saxena and Vicki L. Schlegel27 Metabolomics and Fetal-Neonatal Nutrition: An Overview 357Angelica Dessì, Flaminia Cesare Marincola, and Vassilios Fanos28 Metabolomics, Bioactives, and Cancer 365Shannon R. Sweeney, John DiGiovanni, and Stefano Tiziani29 NMR-Based Metabolomics of Foods 379Takuya Miyakawa, Tingfu Liang, and Masaru Tanokura30 Cancer Chemopreventive Effect of Curcumin through Suppressing Metabolic Crosstalk between Components in the Tumor Microenvironment 388Dong Hoon Suh and Yong-Sang Song31 Metabolomics of Green Tea 397Yoshinori Fujimura and Hirofumi TachibanaPart V Epigenetics 40732 The Potential Epigenetic Modulation of Diabetes Influenced by Nutritional Exposures In Utero 409Jie Yan and Huixia Yang33 The Time has Come (and the Tools are Available) for Nutriepigenomics Studies 418Pearlly S. Yan34 Natural Phytochemicals as Epigenetic Modulators 424Gauri Deb and Sanjay GuptaPart VI Peptidomics 44135 Detection and Identification of Food-Derived Peptides in Human Blood: Food-Derived Short Chain Peptidomes in Human Blood 443Kenji Sato and Daisuke UradoPart VII Nutrigenomics and Human Health 45336 Use of Omics Approaches for Developing Immune-Modulatory and Anti-Inflammatory Phytomedicines 455Shu-Yi Yin, Pradeep M. S., and Ning-Sun Yang37 The Application of Algae for Cosmeceuticals in the Omics Age 476Nyuk Ling Ma, Su Shiung Lam, and Rahman Zaidah38 Gut Microbiome and Functional Foods: Health Benefits and Safety Challenges 489Abhai Kumar, Smita Singh, and Anil Kumar Chauhan39 An Overview on Germinated Brown Rice and its Nutrigenomic Implications 504Mustapha Umar Imam and Maznah Ismail40 Novel Chromium (III) Supplements and Nutrigenomics Exploration: A Review 518Sreejayan Nair, Anand Swaroop, and Debasis BagchiPart VIII Transcriptomics 52541 Transcriptomics of Plants Interacting with Pathogens and Beneficial Microbes 527Hooman Mirzaee, Louise Shuey, and Peer M. Schenk42 Transcriptomic and Metabolomic Profiling of Chicken Adipose Tissue: An Overview 537Brynn H. Voy, Stephen Dearth, and Shawn R. Campagna43 Nutritional Transcriptomics: An Overview 545M. R. Noori-Daloii and A. Nejatizadeh44 Dissecting Transcriptomes of Cyanobacteria for Novel Metabolite Production 557Sucheta Tripathy, Deeksha Singh, Mathumalar C., and Abhishek Das45 Inflammation, Nutrition, and Transcriptomics 573Gareth Marlow and Lynnette R. Ferguson46 Transcriptomics and Nutrition in Mammalians 581Carmen Arnal, Jose M. Lou-Bonafonte, María V. Martínez-Gracia, María J. Rodríguez-Yoldi, and Jesús OsadaPart IX Nutriethics 60947 Nutritional Sciences at the Intersection of Omics Disciplines and Ethics: A Focus on Nutritional Doping 611Nicola Luigi BragazziPart X Nanotechnology 62348 Current Relevant Nanotechnologies for the Food Industry 625Kelvii Wei GuoReferences 634Index 637

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