Fundamentals of Cancer Detection, Treatment, and Prevention
Inbunden, Engelska, 2022
Av Surya K. De, India) De, Surya K. (Conju-Probe, an Diego, USA; Jadavpur University, Kolkata
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Fri frakt för medlemmar vid köp för minst 249 kr.Fundamentals of Cancer Detection, Treatment, and Prevention The professional guide to cancer diagnosis and therapy for researchers and clinicians In Fundamentals of Cancer Detection, Treatment, and Prevention, distinguished researcher Surya K. De delivers a concise and authoritative guide to cancer treatment, diagnosis, and prevention. The book offers a comprehensive overview of cancer in humans, from its causes, symptoms, and diagnosis to the variety of treatment options available today. Intuitively organized by cancer type, this guide provides concise information on risk factors, diagnosis, and treatment options for all commonly encountered tumors, including surgery, radiation therapy, chemotherapy, and immunotherapy. All US FDA-approved drugs—like small molecules, peptides, monoclonal antibodies, whole antibodies, gene therapy, antibody-drug conjugates, and cell therapies—are considered, and information about their generic and brand names, clinical uses, and mechanisms of action is presented. Readers will also find: A thorough overview of human cancers, including cancer risk factors and possible preventionsComprehensive explorations of bladder, blood, brain, and spinal cord cancersPractical discussions of breast, colorectal, cervical, kidney, and liver cancerIn-depth examinations of lung, skin, ovarian, vaginal, vulvar, pancreatic, and prostate cancers, as well as mesotheliomaPerfect for pharmaceutical chemists, oncologists, pharmacologists, and medicinal chemists, Fundamentals of Cancer Detection, Treatment, and Prevention is an indispensable guide for professional researchers, whether they are working in the clinic or the pharmaceutical industry.
Produktinformation
- Utgivningsdatum2022-06-08
- Mått170 x 244 x 29 mm
- Vikt1 077 g
- FormatInbunden
- SpråkEngelska
- Antal sidor496
- FörlagWiley-VCH Verlag GmbH
- ISBN9783527350650
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Surya K. De, PhD, is a principal scientist at Conju-Probe in San Diego, USA. He received his doctorate in organic chemistry from Jadavpur University in Kolkata, India. He is a Fellow of the Royal Society of Chemistry and an elected Councilor in the American Chemical Society.ss
- Preface xxiiiAbout the Book xxvAbout the Author xxviiCommon Abbreviations and Acronyms xxix1 An Overview of Cancer 11.1 Introduction 11.2 Cancer Statistics 11.3 Differences Between Normal Cells and Cancer Cells 21.4 Types of Cancer 41.4.1 Carcinomas 41.4.2 Sarcomas 41.4.3 Leukemias 41.4.4 Lymphomas 41.5 The Role of Genes and Chromosomes 51.6 Genetic Mutations 71.6.1 Acquired Mutations 71.6.2 Germline Mutations 71.7 Genes Connected to Cancer 71.7.1 Tumor Suppressor Genes 71.7.2 Oncogenes 81.7.3 DNA Repair Genes 81.8 Tumors and Metastasis 91.9 Hereditary Cancer Risk 101.10 Cancer Screening and Diagnosis 101.10.1 Colon Cancer 111.10.2 Lung Cancer 111.10.3 Breast/Cervical/Ovarian/Endometrial Cancers 111.10.4 Prostate Cancer 121.10.5 Liver Cancer 121.10.6 Skin Cancer 121.11 Cancer Treatment Options 131.11.1 Surgery 131.11.2 Radiation Therapy 131.11.3 Chemotherapy 141.11.4 Targeted Therapy 141.11.5 Immunotherapy 141.11.6 Hormone Therapy 141.11.7 Stem Cell Transplant 151.11.8 Precision Medicine 15References 152 Cancer Risk Factors and Prevention 212.1 Introduction 212.2 Hormones 212.3 Immunosuppression and Infectious Agents 222.4 Chronic, Long-term, DNA-damaging Inflammation 232.5 Being Overweight/Obese 232.6 Eating to Win 242.6.1 Vegetables 262.6.2 Fruits 262.6.3 Grains 262.6.4 Proteins 262.6.5 Bread 262.6.6 Cereal 262.6.7 Dairy 262.6.8 Snacks 262.6.9 Beverages 262.6.10 Spices 272.7 Role of Sugar and Artificial Sweeteners on Cancer 272.8 Role of Certain Foods and Drinks on Cancer 272.8.1 Processed Meat and Fish 272.8.2 Alcohol 282.9 Role of Smoking or Tobacco Use on Cancer 292.10 Role of Radiation on Cancer 302.11 Role of Sunlight and UV Radiation on Cancer 312.12 Role of Radon on Cancer 332.13 Known Human Carcinogens 332.13.1 Arsenic, Coal Tar, Coal-tar Pitch, Diesel, Asbestos, Formaldehyde, and Air Pollutants 332.13.2 Certain Types of Plastic 372.13.3 Acrylamide 372.14 Possible Human Carcinogens 392.15 Guidelines for Early Detection of Cancer 39References 40Further Reading 503 Bladder Cancer 513.1 Introduction 513.2 Genes Associated with Bladder Cancer 513.3 Types of Bladder Cancer 513.4 Symptoms of Bladder Cancer 523.5 Diagnosis 523.6 Methods of Treatment 533.6.1 Surgical Transurethral Resection of Bladder Tumor (TURBT) 533.6.2 Radiation Therapy 533.6.3 Photodynamic Therapy 533.6.4 Chemotherapy 533.6.5 Targeted Therapy 533.6.6 Immunotherapy 533.7 Treatment Regimens 543.8 Risk Factors/Possible Prevention 57References 574 Cancers of the Blood 674.1 Introduction 674.2 Genes Associated with Blood Cancer 674.3 Types of Blood Cancers 684.4 Blood Cancer Symptoms 704.5 Diagnosis 704.6 Methods of Treatment 704.6.1 Stem Cell Transplantation 714.6.2 Targeted Radiation Therapy 714.6.3 Chemotherapy 714.6.4 Targeted Drug Therapy 714.7 List of Drugs for Different Types of Blood Cancers 714.7.1 Drugs for Acute Lymphoblastic Leukemia 714.7.2 Drugs for Acute Myeloid Leukemia (AML) 714.7.3 Drugs for Chronic Lymphocytic Leukemia 724.7.4 Drugs for Chronic Myelogenous Leukemia (CML) 724.7.5 Drugs for Hairy Cell Leukemia 724.7.6 Drug(s) for Mast Cell Leukemia 724.7.7 Drug(s) for Meningeal Leukemia 724.7.8 Drugs for Hodgkin Lymphoma 724.7.9 Drugs for Non-Hodgkin Lymphoma 724.7.10 Drugs for Multiple Myeloma and Other Plasma Cell Neoplasms 734.8 Leukemia Treatment regimens 734.8.1 Treatment Regimens for Acute Lymphocytic (Lymphoblastic) Leukemia (ALL) 734.8.2 Acute Myeloid (or Myelogenous) Leukemia (AML) Treatment Regimens 764.8.3 Chronic Lymphocytic Leukemia Treatment Regimens 804.8.4 Chronic Myeloid Leukemia (CML) Treatment Regimens 834.8.5 Hairy Cell Leukemia Treatment Regimens 854.9 Hodgkin’s Lymphoma Treatment Regimens 854.10 Non-Hodgkin’s Lymphoma Treatment Regimens 894.11 Cutaneous T-Cell Lymphoma Treatment Regimens 964.12 Primary CNS Lymphoma Treatment Regimens 974.13 Multiple Myeloma Treatment Regimen 984.14 Risk Factors and Possible Preventions 105References 1055 Brain and Spinal Cord Tumors 1335.1 Introduction 1335.2 Genes Associated with Brain Cancer 1335.3 Types of Primary Brain Tumors for Adults 1335.3.1 Astrocytoma 1345.3.2 Oligodendroglioma 1355.3.3 Meningioma 1355.4 Types of Brain Cancer for Children 1355.4.1 Medulloblastoma 1355.4.2 Grade I or II Astrocytoma 1355.4.3 Ependymoma 1355.4.4 Brainstem Glioma 1355.5 Brain Tumor Symptoms 1365.6 Diagnosis 1365.6.1 Neurological Exam 1365.6.2 Imaging Tests 1365.6.3 Biopsy 1375.7 Methods of Treatment 1375.7.1 Surgery 1375.7.2 Radiation Therapy 1375.7.3 Radiosurgery 1375.7.4 Chemotherapy 1375.7.5 Targeted Drug Therapy 1385.8 Treatment Regimens 1385.9 Post-Treatment Rehabilitation 1415.10 Risk Factors/Possible Preventions 141References 1426 Breast Cancer 1516.1 Introduction 1516.2 Genes Associated with Breast Cancer (Pathophysiology) 1516.3 Describing Breast Cancer 1516.4 Breast Cancer Symptoms 1536.5 Diagnosis 1536.5.1 Breast Examination 1536.5.2 Imaging Tests 1536.5.3 Biopsy 1536.6 Methods of Treatment 1546.6.1 Surgery 1546.6.1.1 Lumpectomy 1546.6.1.2 Mastectomy 1546.6.1.3 Sentinel Node Biopsy 1546.6.1.4 Axillary Lymph Node Dissection 1546.6.1.5 Reconstruction 1546.6.2 Radiation Therapy 1546.6.3 Chemotherapy 1556.6.4 Hormone-Blocking Therapy 1556.6.5 Targeted Therapy 1556.6.6 Immunotherapy 1556.6.7 Abbreviations for a Chemotherapy Combination Used to Treat Breast Cancer 1566.6.8 Drugs to Prevent Breast Cancer 1566.7 Drugs for Breast Cancer in Men 1566.8 Treatment Regimens 1576.8.1 Preoperative/Adjuvant Therapy Regimens for HER2-Negative Breast Cancer 1576.8.2 Preoperative/Adjuvant Therapy Regimens for HER2-Positive Breast Cancer 1606.8.3 Systemic Therapy for ER- and/or PR-Positive Recurrent or Stage IV (M1) Disease: HER2-Negative and Postmenopausal or Premenopausal Receiving Ovarian Ablation or Suppression 1626.8.4 Systemic Therapy Regimens for Recurrent/Unresectable/Advanced/ Metastatic Stage IV Breast Cancer: Regimens for HER2-Negative Disease 1656.8.5 Systemic Therapy for ER- and/or PR-Positive Recurrent or Stage IV (M1) Disease: Regimens for HER2-Positive Postmenopausal or Premenopausal Receiving Ovarian Ablation or Suppression 1696.8.6 Systemic Therapy Regimens for Recurrent/Unresectable/Advanced/ Metastatic Stage IV Breast Cancer: Regimens for HER2-Positive Disease 1726.9 Risk Factors/Possible Preventions 176References 1777 Colorectal Cancer 1937.1 Introduction 1937.2 Genes Associated with Colorectal Cancer 1937.3 Colorectal Cancer Symptoms 1937.4 Stages 1957.5 Diagnosis 1957.6 Methods of Treatment 1957.6.1 Surgery 1967.6.2 Radiation Therapy 1967.6.3 Chemotherapy 1967.6.4 Targeted Therapy 1967.6.5 Immunotherapy 1967.7 Drugs to Anal Cancer 1977.8 Drugs to Prevent Anal Cancer 1977.8.1 Treatment Regimens for Colorectal Cancer: Adjuvant/Advanced/Metastatic Disease 1977.8.2 Systemic Therapy for Advanced or Metastatic Disease 1987.8.3 Treatment Regimens for Anal Cancer: Regimens for Localized Stage 2057.8.4 Treatment Regimens for Anal Cancer: Metastatic Stage 2057.9 Risk Factors/Possible Preventions 207References 2078 Cervical Cancer 2198.1 Introduction 2198.2 Causes of Cervical Cancer 2198.3 Symptoms of Cervical Cancer 2198.4 Diagnosis 2208.5 Methods of Treatment 2218.5.1 Surgery 2218.5.2 Radiation Therapy 2218.5.3 Chemotherapy 2218.5.4 Targeted Therapy 2218.5.5 Immunotherapy 2218.6 Vaccines to Prevent Cervical Cancer 2218.7 Treatment Regimens: Systemic Therapy for Recurrent or Metastatic Cervical Cancer 2228.8 Risk Factors/Possible Preventions 225References 2259 Kidney Cancer 2339.1 Introduction 2339.2 Genes Associated with Kidney Cancer 2339.3 Types of Kidney Cancer 2349.4 Kidney Cancer Symptoms 2349.5 Diagnosis 2349.5.1 Urine Tests 2359.5.2 Blood Tests 2359.5.3 Biopsy 2359.5.4 Intravenous Pyelogram 2359.5.5 Ultrasound 2359.5.6 Computed Tomography Scan 2359.5.7 Magnetic Resonance Imaging 2359.5.8 Renal Arteriogram 2359.6 Kidney Cancer Stages 2369.7 Methods of Treatment 2369.7.1 Simple Nephrectomy 2369.7.2 Partial Nephrectomy 2369.7.3 Radical Nephrectomy 2379.7.4 Radiofrequency Ablation 2379.7.5 Arterial Embolization 2379.7.6 Cryotherapy 2379.7.7 Radiation Therapy 2379.7.8 Chemotherapy 2379.7.9 Targeted Drug Therapy 2379.7.10 Immunotherapy 2379.7.11 Complementary or Alternative Treatment 2389.7.12 Drugs for Upper Tract Urothelial Cancer 2389.7.13 Drugs for Wilms’ Tumor and Other Childhood Kidney Cancers 2389.8 Treatment Regimens 2389.9 Risk Factors/Possible Preventions 240References 24110 Liver (Hepatocellular) Cancer 24710.1 Introduction 24710.2 Gene Associated with Liver Cancer and Role of Hepatitis Infection 24710.3 Liver Cancer Symptoms 24710.4 Diagnosis 24810.5 Methods of Treatment 24910.5.1 Surgery 24910.5.2 Liver Transplant 24910.5.3 Ablation Therapies 24910.5.4 Embolization 24910.5.5 Radiation Therapy 24910.5.6 Chemotherapy 24910.5.7 Targeted Therapy 24910.5.8 Immunotherapy 25010.6 Treatment Regimens 25010.7 Liver (Hepatocellular) Cancer Risk Factors/Possible Preventions 252References 25211 Lung Cancer 25911.1 Introduction 25911.2 Genes Associated with Lung Cancer 25911.3 Types of Lung Cancer 26011.4 Symptoms of Lung Cancer 26011.5 Diagnosis 26111.5.1 Imaging Tests 26111.5.2 Sputum Cytology 26211.5.3 Tissue Biopsy 26211.6 Methods of Treatment 26211.6.1 Surgery 26211.6.2 Radiation Therapy 26211.6.3 Chemotherapy 26211.6.4 Targeted Drug Therapy 26211.6.5 Immunotherapy 26311.6.6 Drugs by Types of Lung Cancer 26311.6.6.1 Drugs for Non-Small Cell Lung Cancer 26311.6.6.2 Drugs for Small Cell Lung Cancer 26311.7 Treatment Regimens 26411.7.1 Treatment Regimens for Non-Small Cell Lung Cancer 26411.7.2 Treatment Regimens for Small Cell Lung Cancer 27011.8 Risk Factors and Possible Preventions 273References 27312 Melanoma (Skin Cancer) 28512.1 Introduction 28512.2 Genes Associated with Melanoma 28512.3 Types of Melanoma 28512.3.1 Superficial Spreading Melanoma 28512.3.2 Nodular Melanoma 28612.3.3 Lentigo Maligna Melanoma 28612.3.4 Acral Lentiginous Melanoma 28612.4 Stages of Malignant Melanoma 28612.5 Symptoms of Melanoma Cancer 28712.6 Diagnosis 28712.6.1 Asymmetric 28712.6.2 Border 28712.6.3 Color 28712.6.4 Diameter 28812.6.5 Evolving 28812.7 Methods of Treatment 28812.7.1 Surgery 28812.7.2 Radiation 28812.7.3 Chemotherapy 28812.7.4 Targeted Therapy 28912.7.5 Immunotherapy 28912.7.6 Photodynamic Therapy 28912.8 Drugs for Other Types of Skin Cancer 28912.8.1 Drugs for Basal Cell Carcinoma 28912.8.2 Drugs for Cutaneous Squamous Cell Carcinoma 28912.8.3 Drugs for Merkel Cell Carcinoma 28912.8.4 Drugs for Kaposi Sarcoma 29012.9 Treatment Regimens 29012.10 Melanoma Risk Factors 29312.11 Possible Prevention 29412.11.1 Sun Protection Tips 29412.11.2 What about Vitamin D? 295References 29513 Mesothelioma 30513.1 Introduction 30513.2 Genes Associated with Mesothelioma 30513.3 Types of Mesothelioma Cancers 30513.4 Mesothelioma Cancer Symptoms 30513.4.1 Symptoms for Pleural Mesothelioma 30513.4.2 Symptoms for Peritoneal Mesothelioma 30713.4.3 Symptoms for Pericardial Mesothelioma 30713.4.4 Symptoms for Testicular Mesothelioma 30713.5 Diagnosis 30713.6 Methods of Treatment 30713.6.1 Surgery 30713.6.2 Radiation Therapy 30813.6.3 Chemotherapy 30813.6.4 Targeted Therapy 30813.6.5 Immunotherapy 30813.7 Treatment Regimens 30813.8 Possible Prevention 31013.9 Occupational Exposure Prevention 31013.9.1 Employer Responsibilities 31013.9.2 Employee Responsibilities 31113.10 Household Exposure Prevention 311References 31114 Ovarian, Vaginal, and Vulvar Cancer 31714.1 Introduction 31714.2 Genes Associated with Ovarian, Vaginal, and Vulvar Cancer 31814.3 Symptoms of Ovarian, Vaginal, and Vulvar Cancer 31814.4 Diagnosis 31914.5 Methods of Treatment 32014.5.1 Surgery 32014.5.2 Radiation Therapy 32014.5.3 Chemotherapy 32014.5.4 Hormone Therapy 32014.5.5 Targeted Therapy 32014.6 Drugs for Vaginal Cancer 32014.7 Drugs to Prevent Vaginal Cancer 32114.8 Drugs to Treat Vulvar Cancer 32114.9 Drugs to Prevent Vulvar Cancer 32114.10 Treatment Regimens 32114.10.1 Treatment Regimens for Germ Cell Ovarian Cancer 32714.11 Risk Factors/Possible Preventions 328References 32815 Pancreatic Cancer 34115.1 Introduction 34115.2 Genes Associated with Pancreatic Cancer 34115.3 Symptoms of Pancreatic Cancer 34215.4 Diagnosis 34215.5 Methods of Treatment 34215.5.1 Surgery 34315.5.2 Radiation Therapy 34315.5.3 Chemotherapy 34315.5.4 Targeted Therapy 34315.5.5 Immunotherapy 34315.5.6 Drugs for Gastroenteropancreatic Neuroendocrine Tumors 34315.6 Treatment Regimens for Pancreatic Cancer 34415.7 Risk Factors and Possible Preventions 346References 34716 Prostate Cancer 35516.1 Introduction 35516.2 Genes Associated with Prostate Cancer 35516.3 Symptoms of Prostate Cancer 35616.4 Diagnosis 35616.5 Methods of Treatment 35716.5.1 Surgery 35716.5.2 Radiation Therapy 35716.5.3 Cryotherapy 35716.5.4 Chemotherapy 35816.5.5 Targeted Therapy 35816.5.6 Immunotherapy 35816.5.7 Hormone Therapy 35816.6 Treatment Regimens 35816.7 Risk Factors/Possible Preventions 362References 36317 Stomach (Gastric) Cancer 37117.1 Introduction 37117.2 Genes Associated with Stomach Cancer 37117.3 Symptoms of Stomach Cancer 37217.4 Stages of Stomach Cancer 37317.5 Diagnosis 37417.6 Methods of Treatment 37517.6.1 Surgery 37517.6.2 Endoluminal Stent Placement 37517.6.3 Endoluminal Laser Therapy 37517.6.4 Gastrojejunostomy 37517.7 Radiation Therapy 37617.8 Chemotherapy 37617.9 Targeted Medications 37617.10 Immunotherapy 37617.11 Treatment Regimens for Stomach Cancer 37617.12 Risk Factors 38317.12.1 Certain Medical Conditions 38317.12.2 Smoking 38317.12.3 Helicobacter Pylori Infection 38317.12.4 Family History 38417.12.5 Foods Containing Aflatoxins 38417.12.6 Diet 38417.12.7 Age 38417.12.8 Gender 38417.12.9 Previous or Existing Cancers 38417.12.10 Some Surgical Procedures 38417.13 Possible Preventions 384References 38518 Thyroid Cancer 39518.1 Introduction 39518.2 Genes Associated with Thyroid Cancer 39518.3 Types of Thyroid Cancer 39518.3.1 Papillary Thyroid Cancer 39518.3.2 Follicular Thyroid Cancer 39518.3.3 Medullary Cancer 39618.3.4 Anaplastic Thyroid Cancer 39618.4 Thyroid Cancer Symptoms 39618.5 Diagnosis 39718.6 Staging of Thyroid Cancer 39718.6.1 Papillary or Follicular Thyroid Cancer Patients under the Age of 45 39718.6.2 Papillary or Follicular Thyroid Cancer Patient Aged 45 Years and Older 39718.6.3 Medullary Thyroid Cancer 39818.6.4 Anaplastic Thyroid Cancer 39818.7 Methods of Treatment 39918.7.1 Surgery 39918.7.2 Radioactive Iodine Ablation 39918.7.3 External Beam Radiation 39918.7.4 Thyroid Hormone Therapy 39918.7.5 Chemotherapy 39918.7.6 Targeted Therapy 39918.8 Treatment Regimens 40018.9 Possible Preventions 402References 40219 Endometrial Cancer 40719.1 Introduction 40719.2 Genes Associated with Endometrial Cancer 40719.3 Symptoms 40719.4 Endometrial Cancer Diagnosis 40819.4.1 Internal Pelvic Exam 40819.4.2 Pap Test (also called Pap Smear) 40819.4.3 Endometrial Biopsy 40819.4.4 Dilation and Curettage (Also Called D&C) 40919.4.5 Transvaginal Ultrasound 40919.5 Stages 40919.6 Methods of Treatment 40919.6.1 Surgery 40919.6.1.1 Hysterectomy 41019.6.1.2 Salpingo-oophorectomy 41019.6.1.3 Pelvic Lymph Node Dissection 41019.6.1.4 Para-aortic Lymphadenectomy 41019.6.1.5 Laparoscopic Lymph Node Sampling 41019.6.1.6 Sentinel Lymph Node Mapping 41019.6.2 Radiation Therapy 41019.6.2.1 External Radiation Therapy 41019.6.2.2 Internal Radiation Therapy 41019.6.3 Chemotherapy 41019.6.4 Targeted Therapy 41119.6.5 Immunotherapy 41119.6.6 Hormone Therapy 41119.7 Treatment Regimens 41119.8 Risk Factors of Endometrial Cancer 41519.9 Prevention 415References 41620 Penile Cancer 42320.1 Introduction 42320.2 Symptoms of Penile Cancer 42320.3 Penile Cancer Diagnosis 42420.3.1 Biopsy 42420.3.2 Imaging Tests 42420.4 Methods of Penile Cancer Treatment 42420.4.1 Surgery 42420.4.1.1 Circumcision 42420.4.1.2 Other Surgical Procedures 42520.4.2 Local Treatments (Other than Surgery) for Penile Cancer 42520.4.2.1 Laser Ablation 42520.4.2.2 Cryosurgery/Cryotherapy 42520.4.2.3 Photodynamic Therapy (PDT) 42520.4.3 Radiation Therapy 42520.4.4 Chemotherapy 42520.4.4.1 Topical Chemotherapy 42520.4.4.2 Systemic Chemotherapy 42520.5 Treatment Regimens for Penile Cancer 42520.6 Risk Factors of Penile Cancer 42720.7 Penile Cancer Prevention 427References 42821 Testicular Cancer 43121.1 Introduction 43121.2 Symptoms of Testicular Cancer 43121.3 Diagnosis 43221.3.1 Ultrasound 43221.3.2 A Physical Exam and Medical History 43221.3.3 Blood Tests for Tumor Markers 43221.3.3.1 Biopsy 43321.3.4 CT Scan and X-ray 43321.4 Methods of Treatment 43321.4.1 Surgical Treatment 43321.4.2 Radiation Therapy 43321.4.3 Chemotherapy 43321.5 Treatment Regimens for Testicular Cancer 43321.6 Risk Factors 43521.6.1 An Undescended Testicle 43521.6.2 Family History of Testicular Cancer 43621.6.3 HIV Infection 43621.6.4 Race 43621.6.5 Infertility 43621.6.6 Certain Activities 43621.6.7 Reducing Exposure to Chemical Toxins 43621.7 Prevention 43621.8 Self-Exam of Testicular Cancer 437References 437Index 443
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