Flash Chemistry

Professor Yoshida is head of the synthetic organic chemistry group at Kyoto University Graduate School of Engineering. His research activities concentrate on the development of methods to control and direct organic reactions.

• Preface. 1. Introduction.1.1 Flask Chemistry.1.2 Flash Chemistry.1.3 Flask Chemistry or Flash Chemistry.2. The Background to Flash Chemistry.2.1 How do Chemical Reactions Take Place?3. What is Flash Chemistry?4. Why is Flash Chemistry Needed?4.1 Chemical Reaction, an Extremely Fast Process at Molecular Level.4.2 Rapid Construction of Chemical Libraries.4.3 Rapid Synthesis of Radioactive Position Emission Tomography Probes.4.4 On-Demand Rapid Synthesis in Industry.4.5 Conclusions.5. Methods of Activating Molecules.5.1 Thermal Activation of Organic Molecules.5.2 Photochemical Activation.5.3 Electrochemical Activation.5.4 Chemical Activation.5.5 Accumulation of Reactive Species.5.6 Continuous Generation of Reactive Species in a Flow System.5.7 Interconversion Between Reactive Species.5.8 Conclusions.6. Control of Extremely Fast Reactions.6.1 Mixing.6.2 Temperature Control.6.3 Residence Time Control.6.4 Conclusions.7. Microfluidic Devices and Microflow Systems.7.1 Brief History.7.2 Characteristic Features of Microflow Systems.7.3 Microstructured Fluidic Devices.7.4 Conclusions.8. Applications of Flash Chemistry in Organic Synthesis.8.1 Highly Exothermic Reactions that are Difficult to Control in Macrobatch Reactors.8.2 Reactions in Which a Reactive Intermediate Easily Decomposes in Macrobatch Reactors.8.3 Reactions with Products of Which Easily Decompose in Macrobatch Reactors.8.4 Reactions in Which Undesired By-products are Produced in the Subsequent Reactions In Macrobatch Reactors.8.5 Reactions That Can Be Accelerated Using Microflow Systems.8.6 Conclusions.9. Polymer Synthesis Based on Flash Chemistry.9.1 Introduction.9.2 Chain-Growth Polymerization and Step-Growth Polymerization.9.3 Molecular Weight and Molecular-Weight Distribution.9.4 Cationic Polymerization.9.5 Free-Radical Polymerization.9.6 Conclusions.10. Industrial Applications of Flash Chemistry.10.1 Synthesis of Diarylethene as Photochromic Compound (Micrometer-Size Single-Channel Reactor).10.2 Synthesis of Pharmaceutically Interesting Spiro Lactone Fragment Of Nueropeptide Y (Millimeter-Size Channel-Single Reactor).10.3 Grignard Exchange Process (Internal numbering-up).10.4 Radical Polymerization Process (Numbering-up).10.5 Other examples of Industrial Applications of Flash Chemistry .10.6 Flash Chemistry as a Powerful Means of Sustainable Chemical Synthesis.10.7 Conclusions.11. Outlook of Flash Chemistry.Index.

?The book provides a nice, self-consistent overview of the motivation for flow chemistry, the basic principles of chemical reactions and organic synthesis, and an examination of the concepts of fluid flow, heat and mass transfer, and devices.? (JACS , August 2009) "I found the book very readable and would recommend it to anyone wishing to learn about the benefits of microreactor technology.... The author has structured the book well; the introductory chapters clearly establish the basic concepts of microreactor technology." (Chemistry World, March 2009)