Epigenetics, Nuclear Organization & Gene Function

With implications of epigenetic regulation and genetic architecture for human development and health

Häftad, Engelska, 2019

Av John C. Lucchesi, USA) Lucchesi, John C. (Asa Griggs Candler Professor Emeritus, Asa Griggs Candler Professor Emeritus, Department of Biology, Emory University, Atlanta GA

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Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine.This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

Produktinformation

Utgivningsdatum2019-01-15
Mått190 x 247 x 15 mm
Vikt634 g
FormatHäftad
SpråkEngelska
Antal sidor306
FörlagOUP OXFORD
ISBN9780198831211

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Biovetenskap inom Naturvetenskap och teknik

John Lucchesi obtained a Ph.D. in Genetics from the University of California at Berkeley. Following postdoctoral training in the Institute of Molecular Biology at the University of Oregon, he joined the faculty of the University of North Carolina in Chapel Hill, where he rose to the rank of Cary C. Boshamer Professor of Biology and Genetics. He was appointed Adjunct Professor of Genetics at Duke University and was named Senior Fellow of Churchill College, Cambridge University, UK. In 1990, he joined the faculty of the Biology Department at Emory University as Asa G. Candler Professor of Biology and Chair. Dr Lucchesi is a fellow of the AAAS, a former President of the Genetics Society of America and was named Vice-President of the XVII International Congress of Genetics. His research laboratory has focused on the regulation of transcription, the functional architecture of chromatin and the genetic regulation of development.

Part IAn introduction to epigenetics and epigenetic regulation1: Epigenetic phenomena in fungi, plants and animals2: The basic structure of chromatin3: The basic mechanism of gene transcriptionPart IITranscription is regulated by epigenetic mechanisms4: Chromatin modifications and remodeling5: Epigenetic chromatin changes and the transcription cycle6: The role of non-coding RNAs7: Maintenance of the active and inactive states8: DNA methylation and gene expression9: Regulation of domains and whole chromosomesPart IIIThe interplay between transcription and nuclear structure10: Architectural organization of the genome11: The nuclear envelope12: The nucleolus13: Nuclear bodiesPart IVInheritance of chromatin structure and functional states14: Chromosome replication and genomic stability15: DNA repair and genomic stability16: Inheritance of chromatin modifications through the cell cycle17: Stem cells18: Nuclear reprogramming and induced pluripotency19: Transgenerational inheritance of epigenetic traitsPart VEpigenetics, human health and development20: Aging, cellular senescence and cancer: The role of genomic instability, cellular homeostasis and telomeres21: Aging, cellular senescence and cancer: Epigenetic alterations and nuclear remodeling22: Developmental systems and their dysfunction

This book provides a high-quality and accessible overview of the field of epigenetics, with content organized in a logical sequence . . . [it is] a highly cohesive, logical, and useful volume in which significant content areas are insightfully drawn from the expansive field of epigenetics. It is apparent that the book is written by an individual with a strong breadth of knowledge accumulated from a distinguished career in the field . . . this book, therefore, will be an excellent resource for both those new to epigenetics and seasoned experts