Emerging Targets in Antibacterial and Antifungal Chemotherapy

• Antibacterial Chemotherapy.- 1. Historical Perspectives of Approaches to Antibiotics Discovery.- 2. Bacterial Pathogens for the 1990s: A Case for New Drug Development.- 3. DNA Replication.- 4. RNA Synthesis in Bacteria: Mechanism and Regulation of Discrete Biochemical Events at Initiation and Termination.- 5. Bacterial Cell Division.- 6. Fatty Acid Biosynthesis.- 7. Protein Secretion in Bacteria: A Chemotherapeutic Target?.- 8. Cytosolic Enzymes in Peptidoglycan Biosynthesis as Potential Antibacterial Targets.- 9. Strategies in ?-lactam Design.- 10. Lipid A Biosynthesis.- 11. Compromising the Protective Barrier of the Gram-Negative Bacterial Cell Surface.- 12. Bacterial Virulence Factors as Targets for Chemotherapy.- Antifungal Chemotherapy.- 13. Invasive Fungal Infections: Problems and Challenges for Developing New Antifungal Compounds.- 14. Topoisomerase II Inhibitors: Prospects for New Antifungal Agents.- 15. Functions for Sterols in Yeast Membranes.- 16. Biochemical Aspects of Ergosterol Biosynthesis Inhibition.- 17. Rationally Designed Inhibitors of Sterol Biosynthesis.- 18. Chitin Synthase as a Chemotherapeutic Target.- 19. Glucan Biosynthesis in Fungi and its Inhibition.- 20. Virulence-Associated Mannoproteins in Candida Albicans.- 21. Screening for Antifungal Activity.- 22. Chemotherapeutic Targets in Pneumocystis Carinii.

This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School