Dyneins

Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.

• I History and EvolutionChapter 1 Discovery of Dynein and its Properties : A Personal AccountChapter 2 Evolutionary Biology of DyneinsII Structure and Mechanics of Dynein MotorsChapter 3 The AAA+ Powerhouse-Trying to Understand How it WorksChapter 4 Dynein Motor MechanismsChapter 5 Structural Analysis of Dynein Intermediate and Light ChainsChapter 6 Biophysics of Dynein In VivoIII Dyneins in Ciliary BiologyChapter 7 Composition and Assembly of Axonemal DyneinsChapter 8 Organization of Dyneins in the AxonemeChapter 9 Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other OrganismsChapter 10 Regulation of Axonemal Outer-Arm Dyneins in CiliaChapter 11 Control of Axonemal Inner Dynein ArmsChapter 12 Flagellar Motility and the Dynein Regulatory ComplexChapter 13 Regulation of Dynein in Ciliary and Flagellar MovementChapter 14 Dynein and Intraflagella TransportIV Cytoplasmic Dynein BiologyChapter 15 Cytoplasmic Dynein Function Define by Subunit CompositionChapter 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of Chapter 17 Insights into Cytoplasmic Dynein Function and Regulation from Fungal GeneticsChapter 18 Genetic Insights in to Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in MouseChapter 19 Role of Dynactin in Dynein-mediated MotilityChapter 20 Roles of Cytoplasmic Dynein during MitosisV Dynein Dysfunction and DiseaseChapter 21 Does Dynein Influence the Non –Mendelian Inheritance of Chromosome 17 Homologs in Male Mice?Chapter 22 Role of Dynein in Viral PathogenesisChapter 23 Cytoplasmic Dynein Dysfunction and Neurodegenerative DiseaseChapter 24 Dynein Dysfunction as a Cause of Primary Ciliary Dyskinesia and Other Ciliopathies