Dyneins

Structure, Biology and Disease

Häftad, Engelska, 2016

Av Stephen M. King, University of Connecticut Health Center) King, Stephen M. (Professor, Department of Molecular Biology and Biophysics Director, Electron Microscopy Facility

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Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over 100 streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine.

Broad-based up-to-date resource for the dynein class of molecular motors
Chapters written by world experts in their topics
Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features

Produktinformation

Utgivningsdatum2016-08-19
Mått191 x 235 x undefined mm
Vikt1 340 g
FormatHäftad
SpråkEngelska
Antal sidor656
FörlagElsevier Science
ISBN9780128103715

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Anatomi inom Medicin

Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.

I History and EvolutionChapter 1 Discovery of Dynein and its Properties : A Personal AccountChapter 2 Evolutionary Biology of DyneinsII Structure and Mechanics of Dynein MotorsChapter 3 The AAA+ Powerhouse-Trying to Understand How it WorksChapter 4 Dynein Motor MechanismsChapter 5 Structural Analysis of Dynein Intermediate and Light ChainsChapter 6 Biophysics of Dynein In VivoIII Dyneins in Ciliary BiologyChapter 7 Composition and Assembly of Axonemal DyneinsChapter 8 Organization of Dyneins in the AxonemeChapter 9 Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other OrganismsChapter 10 Regulation of Axonemal Outer-Arm Dyneins in CiliaChapter 11 Control of Axonemal Inner Dynein ArmsChapter 12 Flagellar Motility and the Dynein Regulatory ComplexChapter 13 Regulation of Dynein in Ciliary and Flagellar MovementChapter 14 Dynein and Intraflagella TransportIV Cytoplasmic Dynein BiologyChapter 15 Cytoplasmic Dynein Function Define by Subunit CompositionChapter 16 Studies of Lissencephaly and Neurodegenerative Disease Reveal Novel Aspects of Chapter 17 Insights into Cytoplasmic Dynein Function and Regulation from Fungal GeneticsChapter 18 Genetic Insights in to Mammalian Cytoplasmic Dynein Function Provided by Novel Mutations in MouseChapter 19 Role of Dynactin in Dynein-mediated MotilityChapter 20 Roles of Cytoplasmic Dynein during MitosisV Dynein Dysfunction and DiseaseChapter 21 Does Dynein Influence the Non –Mendelian Inheritance of Chromosome 17 Homologs in Male Mice?Chapter 22 Role of Dynein in Viral PathogenesisChapter 23 Cytoplasmic Dynein Dysfunction and Neurodegenerative DiseaseChapter 24 Dynein Dysfunction as a Cause of Primary Ciliary Dyskinesia and Other Ciliopathies