Dyneins

The Biology of Dynein Motors

Inbunden, Engelska, 2017

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Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters.

Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology.

Presents a broad-based, up-to date view of the biology of dynein motors
Discusses approaches from genetics, molecular biology, biochemistry and biophysics
Includes a companion website with movies of dynamic cell behavior
Covers the topic in comprehensive chapters written by world experts

Produktinformation

Utgivningsdatum2017-11-22
Mått191 x 235 x 40 mm
Vikt1 560 g
FormatInbunden
SpråkEngelska
Antal sidor684
Upplaga2
FörlagElsevier Science
ISBN9780128094716

Tillhör följande kategorier

Cellbiologi inom Naturvetenskap och teknik

Stephen M. King is Professor of Molecular Biology and Biophysics at the University of Connecticut School of Medicine and is also director of the electron microscopy facility. He has studied the structure, function and regulation of dyneins for over 30 years using a broad array of methodologies including classical/molecular genetics, protein biochemistry, NMR structural biology and molecular modeling, combined with cell biological approaches, imaging and physiological measurements.

I. History and Evolution1. Discovery of dynein and its properties: a personal account2. Origins of cytoplasmic dynein3. The evolutionary biology of dyneinsII. Dyneins in Ciliary Biology4. Cytoplasmic preassembly and trafficking of axonemal dyneins5. Composition and assembly of axonemal dyneins6. Organization of dyneins in the axoneme7. Genetic approaches to axonemal dynein function in Chlamydomonas and other organisms8. Regulatory mechanics of outer arm dynein motors9. Control of axonemal inner dynein arms10. Ciliary and flagellar motility and the nexin-dynein regulatory complex11. Regulation of dynein-driven ciliary and flagellar movement12. Dynein-mediated photobehavioral responses in Chlamydomonas13. Dynein and intraflagellar transportIII. Cytoplasmic Dynein Biology14. Cytoplasmic dynein function defined by subunit composition15. Regulation of cytoplasmic dynein motility16. Insights into cytoplasmic dynein function and regulation from fungal genetics17. Role of dynactin in dynein-mediated motility18. Role of cytoplasmic dynein and dynactin in mitotic checkpoint silencing19. Cytoplasmic dynein during mitosis20. Dynein and dynactin at microtubule plus ends21. Drosophila cytoplasmic dynein: mutations, tools and developmental functions