Drug Evaluation in Angina Pectoris

Häftad, Engelska, 2012

Av Gianluigi Ardissino, Lionel H. Opie, Stefano Savonitto

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Although there are many books on angina, few are devoted to the important problem of how to evaluate drug efficacy in angina pectoris.

Produktinformation

Utgivningsdatum2012-10-08
Mått178 x 254 x 16 mm
Vikt540 g
FormatHäftad
SpråkEngelska
SerieDevelopments in Cardiovascular Medicine
Antal sidor262
FörlagSpringer-Verlag New York Inc.
ISBN9781461361275

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I. Pathophysiology, Clinical Presentation, and Prognosis of Angina Pectoris.- 1. Pathophysiology, Clinical Presentation, and Prognosis of Angina Pectoris.- II. Evaluation of the Patient with Angina Pectoris.- 2. Clinical Value of Anginal Symptoms and their Assessment in Drug Trials.- 3. Quality of Life Assessments in Clinical Trials of Angina Pectoris.- 4. Optimizing the Exercise Test for Pharmacological Studies in Patients with Angina Pectoris.- 5. Evaluation of Transient Myocardial Ischemia by Holtet Monitoring.- 6. Radionuclide Methods for the Evaluation of Ventricular Function and Thrombolytic Therapy.- 7. Provocative Testing of Coronary Vasoconstriction.- 8. Pharmacological Investigation Using Invasive Methods.- III. Planning, Conducting, and Evaluating Clinical Trials in Angina Pectoris.- 9. Patient Selection and Definition of Study Endpoints.- 10. Controlling Potential Sources of Bias in Clinical Trials of Antianginal Agents.- 11. Parallel-Group and Crossover Designs for Drug Evaluation in the Various Forms of Angina Pectoris.- 12. Dose-Response Relationships and Combination Studies with Antianginal Agents.- 13. Sample Size and Power of Clinical Trials.- 14. Multicenter Trials: Design and Conduct.- IV. Critical Issues Related to Specific Antianginal Agents.- 15. Experimental Evaluation and Clinical Relevance of Tolerance to Nitrates.- 16. Clinical Evaluation of Beta-blockers in Various Forms of Angina Pectoris.- 17. Efficacy and Safety of Calcium Antagonists as Antianginal Agents.- 18. Effects of Antithrombotic Agents on Mortality and Nonfatal Cardiac Events.- 19. The Challenge of Thrombolytic Therapy in Unstable Angina Pectoris.- V. Regulatory Aspects Related to the Evaluation of New Antianginal Agents.- 20. Comments on the Food and Drug Administration (FDA) Cardiac and Renal Drugs Advisory Committee Recommended Guidelines for the Conduct of Antianginal Drug Trials.- 21. European Communities’ Committee for Proprietary Medicinal Products (CPMP) Working Party on Efficacy of Medicinal Products.

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