Drug Discovery Targeting Metalloenzymes

Guo-Bo Li is Professor in the Department of Medicinal Chemistry at Sichuan University, China. His research group now focuses on development of new computational tools, new data resources and new web servers to assist basic science and drug discovery research particularly targeting metalloenzymes, and development of new chemical probes, new hits/leads or drug candidates to exploit metalloenzyme biological/pathological roles and therapeutical potentials.

• 1. Advances in Database and Computational Tools for Drug Discovery Targeting Metalloenzymes2. Metal-Binding Pharmacophores for Metalloenzyme Drug Discovery3. Multiscale Computational Approaches in Metal?Ligand Interactions in Drug Design4. Modelling Metalloenzyme Catalytic Mechanisms by QM/MM Calculations5. Metalloenzyme-specific Scoring Function6. Experimental Strategies in Metalloenzyme Mechanism Study and Drug Discovery7. Structural and Chemical Biology of 2-Oxoglutarate-dependent Oxygenases8. MBL-fold Nucleases in DNA Repair and Drug Discovery9. Regulatory, Inhibitory Mechanisms and Drug Discovery of Tryptophan/Indoleamine 2,3-Dioxygenase (TDO/IDO)10. Histone Deacetylase Inhibitor Discovery11. Drug Discovery Targeting Phosphodiesterases12. Metalloenzymes in RNA metabolism13. Targeting Metallo-¿-lactamases to Combine Antibiotic Resistance14. Structural Insights and Drug Discovery into Cytochrome P450 Enzymes15. Drug Discovery Targeting Viral Metalloenzymes16. Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors17. Drug Discovery Targeting Membrane Metalloenzyme CD7318. Targeting Carbonic Anhydrases for Disease Treatment19. Bacterial LpxC Inhibitor Discovery20. Drug Discovery Targeting Human and Fungal CYP5121. Targeting Autotaxin (ATX) for Therapeutic Intervention