This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process.
Introduction.- Development of a Mirror-image Screening Process by Using Synthetic Proteins.- Synthesis of Grb2 SH2 Domain Proteins for Mirror-image Screening Systems.- Conclusions.