Dermal Drug Selection and Development

An Industrial Perspective

Inbunden, Engelska, 2017

Av Lionel Trottet, Howard Maibach, MD, Howard Maibach MD, Md Maibach

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The authors show how the pharmaceutical industry faces the development of dermal drugs and provide the only book of its kind that describes how the industry develops and selects dermal drugs, complete with the challenges and opportunities of the field.

Produktinformation

Utgivningsdatum2017-08-16
Mått155 x 235 x 15 mm
Vikt418 g
FormatInbunden
SpråkEngelska
Antal sidor148
Upplaga17001
FörlagSpringer International Publishing AG
ISBN9783319595030

Tillhör följande kategorier

Kemi inom Naturvetenskap och teknik
Dermatologi inom Medicin

Lionel Trottet, PhD is a DMPK Unit Manager, Drug Discovery chez Oncodesign in France. He has 20 years of expertise in Dermatology (dermal drug discovery, pharmacokinetics, PK/PD and formulation), 18 years of experience in general pharmacokinetics, drug metabolism and PK/PD, 13 years of experience as a DMPK representative in Drug Discovery projects, and 8 years of experience as a DMPK manager.Howard Maibach, MD is an expert in contact and occupational dermatitis and sees patients at the Environmental Dermatosis Clinic, which is part of the Dermatology Clinic at University of California, San Francisco (UCSF). His specialty is dermatotoxicology, or skin exposure toxicity; allergies and skin disorders; and dermatopharmacology or the study of medications for skin disorders. Dr. Maibach has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society and the Internal Commission on Occupation Health. He is a professor in the Department of Dermatology at UCSF.

Introduction.- Choosing the topical drug candidate.- Key factors affecting the efficacy of a topical drug candidate.- Topical vs. Oral/systemic Drug discovery.- Assessing drug concentration in skin.- Assessing Topical efficacy.- Assessing the therapeutic index.- Topical vehicle selection.- Topical drug development strategies.- Topical drug candidate selection criteria and cascade.- Selecting a dermal drug candidate.- Conclusions and perspectives.

“This book provides some valuable insights into the challenges related to the design and development of dermatopharmaceuticals. As such, this book is expected to be well received by the scientific community involved in this kind of research. … this book should serve as a reference for anyone interested in developing dermatopharmaceuticals. … Written by an expert in drug delivery, this book provides an overview of challenges the industry faces in selecting and developing a dermal product.” (Rahmat M. Talukder, Doody's Book Reviews, September, 2017)