Clinical Aspects of Multiple Sclerosis Essentials and Current Updates

Dr. Shitiz K. Sriwastava, MD, is an Assistant Professor in the Department of Neurology with the Division of Multiple Sclerosis and Neuroimmunology at the University of Texas Health Science Center – Houston (UTHealth). He is a board-certified neurologist specialized in multiple sclerosis (MS). During his fellowship training and residency at Wayne State, he performed clinical research on MS and related autoimmune disorders of the central nervous system. He has had many years of experience in MS related clinical trials as a fellow or co-investigator. Dr. Sriwastava has a keen interest in identifying prognostic markers to predict the initiation and progression of MS especially early neurogenerative changes and also DTI studies in MS. He is currently a member of the American Academy of Neurology. His clinical, basic and translational studies in neuroimmunologic diseases have resulted in 50 peer reviewed papers and reports, published abstracts from national and international meetings.Evanthia Triantafylou-Bernitsas, MD, joined the Department of Neurology at Wayne State University in 2011. She has completed a neurology residency at Case Western Reserve University and Neuroimmunology Fellowships at the University of Michigan and Baylor College of Medicine. She is the Director of the Multiple Sclerosis Center at Wayne State School of Medicine and Professor of Neurology. Her clinical research focuses on aggressive forms of MS, new immunomodulatory therapies and symptomatic interventions. Dr. Bernitsas directs a very active clinical research program and she is the principal investigator on numerous clinical and investigator-initiated trials. Currently, she serves as the Editor-in Chief in the Neuroimaging section of the Brain Sciences journal. She has published extensively and served in several committees and advisory boards.

• Introduction of multiple sclerosis and its subtypes, including the new terms clinically isolated syndrome and radiologically isolated syndrome, and diagnostic criteria including McDonald 2017 updatesIntroduction to neuromyelitis optica spectrum disordersMultiple sclerosis epidemiology, epigenetics, and causative factorsNonmultiple sclerosis demyelinating disorders and common mimickers and masquerading of multiple sclerosisCurrent and emerging therapies in multiple sclerosis and practice guidelinesPediatric multiple sclerosis and current guidelines on DMT therapy in pediatric MSPrepregnancy, pregnancy, and postpregnancy planning in patients with multiple sclerosisRare variant of multiple sclerosisImaging of multiple sclerosis, related disorders, and emerging conceptsApplication of optical coherence tomography and angiography in multiple sclerosisCognitive impairment in multiple sclerosis

"...[a] comprehensive guide covers recent advances in multiple sclerosis (MS), neuromyelitis optica spectrum disorders, and conditions that can mimic MS like Behcet’s disease, Susac syndrome, adult-onset leukodystrophies, sarcoidosis, and Sjogren’s syndrome. [P]rovide insights into research and clinical developments for neuroscientists, neurologists, and students in training who want to learn more about MS [which] includes management of special pediatric and pregnant populations and differentiation of MS from related neuro-immunologic conditions that often mimic it.... [Has] a helpful table of contents that provides a nice outline of the topics.... Each chapter starts with a helpful list of abbreviations, subheadings, figures, and tables, and ends with a comprehensive list of references. [W]ell-written and offers a useful introduction to MS, encompassing both pathogenesis and diagnostic criteria. It does a great job of reviewing several key topics related to complex diseases like MS, and the many advances that have developed over the past few decades. [P]rovides clinicians with a helpful framework to help with understanding, diagnosis, and treating patients with this disease. For researchers, it highlights many areas where additional research is needed and it describes tools, such as optical coherence tomography (OCT) and OCT angiography, that can be useful in this pursuit. [W]ell-organized and its inclusion of related disorders, which can frequently mimic MS, will help readers distinguish and differentiate. The extensive list of references at the end of each chapter helps provide directions for further study. Lastly, readers are left with inspiration to develop their own insights on these complex diseases that affect so many patients worldwide." --©Doody’s Review Service, 2024, Nara Michaelson, MD (Massachusetts General Hospital)