Chemogenomics and Chemical Genetics

A User's Introduction for Biologists, Chemists and Informaticians

Häftad, Engelska, 2016

AvERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère

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High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms.

Produktinformation

Utgivningsdatum2016-08-23
Mått178 x 254 x 15 mm
Vikt518 g
FormatHäftad
SpråkEngelska
Antal sidor256
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783662519912

Tillhör följande kategorier

Kemi inom Naturvetenskap och teknik
Biokemisk teknik inom Naturvetenskap och teknik
Biovetenskap inom Naturvetenskap och teknik
Fysikalisk kemi inom Naturvetenskap och teknik

The pharmacological screening process:the small molecule, the biological target, the robot, the signal and the information.- Collections of molecules for screening: example of the French National Chemical Library.- The miniaturised biological assay: constraints and limitations.- The signal: statistical aspects, standardisation, elementary analysis.- Measuring bioactivity: Ki, IC50 and EC50.- Modelling the pharmacological screening:controlling the processes and the chemical, biological and experimental information.- Quality procedures in automated screening.- Phenotypic screening of cells and the strategies for direct chemical genetics.- High information content screens for forward (phenotypic screening of organisms) and reverse (structural screening by NMR) chemical genetics.- Some principles of Diversity-Oriented Synthesis.- Molecular descriptors and similarity indices.- Lipophilicity of molecules: a predominant descriptor for QSAR.- The annotation and classification of chemical space in chemogenomics.- The annotation and classification of biological space in chemogenomics.- Machine learning and screening data.- Virtual screening by molecular docking.- Biodiversity as a source of small molecules for pharmacological screening: libraries of plant extracts.