Cell Death

Hao Wu, Ph.D., is the Asa and Patricia Springer Professor at Harvard Medical School where she is a member of the Department of Biological Chemistry and Molecular Pharmacology. She is also a Senior Investigator in the Program in Cellular and Molecular Medicine at Boston Children’s Hospital. Her research focuses on elucidating the molecular basis of signal transduction by immune receptors, including the induction of cell death pathways.

• 1. Historical Perspective – the Seven Ages of Cell Death Research.- 2. The Intrinsic Apoptotic Pathway.- 3. Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis.- 4. Bcl-2 family and their therapeutic potential.- 5. IAP proteins and their therapeutic potential.- 6. Cell Death and Cancer.- 7. The DNA damage response mediates apoptosis and tumor suppression.- 8. Neuronal Death Mechanisms in Development and Disease.- 9. The Complex Interplay Between Metabolism and Apoptosis.- 10. Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death.- 11. Structural Perspectives on BCL-2 Family of Proteins.- 12. Structural basis of death receptor signaling.

From the book reviews: "This new book comprises reviews of primary studies that elucidate apoptotic pathways in specialized cells and suggest points of intervention for the treatment of various cancers. ... Summing Up: Highly recommended. Upper-division undergraduates through professionals." (S. K. Sommers Smith, Choice, Vol. 51 (11), August, 2014)