Cardio-renal syndrome

Kidney failure is detected in over a third of heart failure patients. The association of these two pathologies has a poor prognosis, as it often alters the therapeutic strategy recommended for heart failure patients, and increases the progressive damage to both organs. The kidney plays an important role in the pathophysiology of heart failure, and suffers the progressive consequences of the most common causes of heart failure: ventricular dysfunction, atherosclerosis, hypertension and diabetes. Because these patients with renal failure and heart failure are often excluded from controlled trials, little is known about their optimal treatment and recommended medications. The "cardio-renal" syndrome is a hot topic, with various studies highlighting its increasing frequency and therapeutic implications. It can have detrimental consequences, as it exacerbates the effects of neurohormonal stimulation, inflammation, oxidative stress and endothelial dysfunction on the structure of the myocardium, vessels and kidneys.