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Proceedings of an international workshop and plenary meeting entitled Towards Clinical Trials of Glioma with Boron Neutron Capture Therapy, held September 18-20, 1991, in Petten, The Netherlands
Opening Speech.- Welcome Address.- Safety and Efficacy in Boron Neutron Capture Therapy.- Some Aspects of BNCT Research at the BrookhavenNational Laboratory.- INEL BNCT Program Directions with Respect to Clinical Trials of BNCT.- The Department of Energy Research Program in Boron Neutron Capture Therapy.- Current Overview on the Approach of Clinical Trials at Petten.- Review of the Physics Calculations Performed for the BNCT Facility at the HFR Petten.- From Filter Installation to Beam Characterization.- Neutron Spectrometry Measurements of the Petten HFR, HB11 Neutron Beam.- A Semi-Empirical Method of Treatment Planning for Boron Neutron Capture Therapy.- Present Status of the Three-Dimensional Treatment Planning Methodologies for the Petten BNCT Facility.- A Phase 1 Biodistribution Study of P-Boronophenylalanine.- RBE in Normal Tissue Studies.- Treatment Planning and Optimization for Pion Therapy.- Dose Calculations Based on Image Reconstructions.- Borocaptate Sodium (BSH) Pharmacokinetics in Glioma Patients.- BSH in Patients with Malignant Glioma: Distribution in Tissues, Comparison Between BSH Concentration and Histology.- Macroscopic and Microscopic Biodistribution of Bsh in a Rat Glioma Model.- Healthy Tissue Tolerance Studies for BNCT at the High Flux Reactor in Petten - First Results.- Cellular Pharmacokinetics of BNCT Compounds and their Cellular Localization with EELS/ESI.- Large Animal Model Studies of Normal Tissue Tolerance Using an Epithermal Neutron Beam and Borocaptate Sodium.- Proposal for Patient Selection Criteria and Follow-Up for BNCT in Patients with Supratentorial Malignant Gliomas.- A Proposal for Phase I Clinical Trials of Glioma Patients.- Approaches to the Design and Evaluation of Compounds for BNCT.- The Implementation Strategy for BNCT Trials in Australia.- Round Table Discussion Approach to Clinical Trials of Glioma.- Author Index.- Participants.
