Boron-Based Compounds

Potential and Emerging Applications in Medicine

Inbunden, Engelska, 2018

AvEvamarie Hey-Hawkins,Clara Viñas Teixidor,Clara Vinas Teixidor

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Noted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the fieldOffers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnosticsHighlights the range and capacity of boron-based compounds in medical applicationsIncludes information on boron neutron capture therapy and diagnosticsDesigned for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.

Produktinformation

Utgivningsdatum2018-05-04
Mått175 x 244 x 25 mm
Vikt1 089 g
FormatInbunden
SpråkEngelska
Antal sidor496
FörlagJohn Wiley & Sons Inc
ISBN9781119275558

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Prof. Dr. Evamarie Hey-Hawkins has been a Full Professor of Inorganic Chemistry at Leipzig University since 1993. Her research interests include the synthesis of novel reagents for BNCT and use of boron clusters as pharmacophores or modulators for biomolecules. Prof. Dr. Clara Viñas Teixidor is a Research Professor at the Institut de Ciència de Materials de Barcelona, Spanish Council for Scientific Research, Spain. Her fields of research involve synthesis and derivatisation of boron clusters to be applied in medicine and biosensing, among others. Previously, she worked in industry and at public institutions involved in food science analysis as well as environmental control.

List of Contributors viiPreface xiPart 1 Design of New Boron‐based Drugs 11.1 Carboranes as Hydrophobic Pharmacophores: Applications for Design of Nuclear Receptor Ligands 3Yasuyuki Endo1.2 Boron Cluster Modifications with Antiviral, Anticancer, and Modulation of Purinergic Receptors’ Activities Based on Nucleoside Structures 20Anna Adamska‐Bartłomiejczyk, Katarzyna Bednarska, Magdalena Białek‐Pietras, Zofia M. Kiliańska, Adam Mieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Zofia Sułowska, Jolanta D. Żołnierczyk, and Zbigniew J. Lesnikowski1.3 Design of Carborane‐Based Hypoxia‐Inducible Factor Inhibitors 35Guangzhe Li, Hyun Seung Ban, and Hiroyuki Nakamura1.4 Half‐ and Mixed‐Sandwich Transition Metal Dicarbollides and nido‐Carboranes(–1) for Medicinal Applications 60Benedikt Schwarze, Marta Gozzi, and Evamarie Hey‐Hawkins1.5 Ionic Boron Clusters as Superchaotropic Anions: Implications for Drug Design 109Khaleel I. Assaf, Joanna Wilinska, and Detlef Gabel1.6 Quantum Mechanical and Molecular Mechanical Calculations on Substituted Boron Clusters and Their Interactions with Proteins 126Jindřich Fanfrlík, Adam Pecina, Jan Řezáč, Pavel Hobza, and Martin LepšíkPart 2 Boron Compounds in Drug Delivery and Imaging 1392.1 Closomers: An Icosahedral Platform for Drug Delivery 141Satish S. Jalisatgi2.2 Cobaltabisdicarbollide‐based Synthetic Vesicles: From Biological Interaction to in vivo Imaging 159Clara Viñas, Francesc Teixidor, and Adrian J. Harwood2.3 Boronic Acid–Based Sensor for Determination of Sugars 174Igor B. Sivaev and Vladimir I. Bregadze2.4 Boron Compounds in Molecular Imaging 205Bhaskar C. Das, Devi Prasan Ojha, Sasmita Das, and Todd Evans2.5 Radiolabeling Strategies for Boron Clusters: Toward Fast Development and Efficient Assessment of BNCT Drug Candidates 232Kiran B. Gona, Vanessa Gómez‐Vallejo, Irina Manea, Jonas Malmquist, Jacek Koziorowski, and Jordi LlopPart 3 Boron Compounds for Boron Neutron Capture Therapy 2693.1 Twenty Years of Research on 3‐Carboranyl Thymidine Analogs (3CTAs): A Critical Perspective 271Werner Tjarks3.2 Recent Advances in Boron Delivery Agents for Boron Neutron Capture Therapy (BNCT) 298Sunting Xuan and Maria da Graça H. Vicente3.3 Carborane Derivatives of Porphyrins and Chlorins for Photodynamic and Boron Neutron Capture Therapies: Synthetic Strategies 343Valentina A. Ol’shevskaya, Andrei V. Zaitsev, and Alexander A. Shtil3.4 Nanostructured Boron Compounds for Boron Neutron Capture Therapy (BNCT) in Cancer Treatment 371Shanmin Gao, Yinghuai Zhu, and Narayan Hosmane3.5 New Boronated Compounds for an Imaging-Guided Personalized Neutron Capture Therapy 389Nicoletta Protti, Annamaria Deagostino, Paolo Boggio, Diego Alberti, and Simonetta Geninatti Crich3.6 Optimizing the Therapeutic Efficacy of Boron Neutron Capture Therapy (BNCT) for Different Pathologies: Research in Animal Models Employing Different Boron Compounds and Administration Strategies 416Amanda E. Schwint, Andrea Monti Hughes, Marcela A. Garabalino, Emiliano C.C. Pozzi, Elisa M. Heber, and Veronica A. TrivillinIndex