Biomedical Sciences

Professor Ray Iles and Dr Suzanne Docherty, School of Health & Social Sciences, Middlesex University, Hendon Campus, London, UK.Ray Iles has experience of writing a chapter of Kumar & Clark's Clinical Medicine (one of the market leading textbooks for medical students) and would like to provide the same kind of core textbook for biomedical science students.

• List of Contributors xiPreface xiiiChapter 1 Anatomy and physiology of major organ systems 1Ray K. Iles, Iona Collins and Suzanne M. Docherty1.1 The skeletal system 11.2 The digestive system 61.3 The cardiovascular system 111.4 The urinary system 171.5 Respiratory system 211.6 The nervous system 231.7 The endocrine system 31Bibliography 33Chapter 2 Pathophysiology 35Suzanne M. Docherty2.1 Pathophysiology: a definition 352.2 Introduction to epidemiology 352.3 Introduction to pharmacology 382.4 Gastroenterology 442.5 Liver, biliary tract and pancreatic disease 502.6 Rheumatology 562.7 Urinary tract disease 592.8 Cardiovascular disease 652.9 Respiratory disease 762.10 Endocrine disease 80Bibliography 88Chapter 3 Clinical cell biology and genetics 89Ray K. Iles and Stephen A. Butler3.1 The cell 893.2 Genetics 1033.3 Human genetic disorders 1163.4 Important techniques in molecular cell biology 136Bibliography 138Chapter 4 Cellular pathology 139Christopher M. Stonard and Jennifer H. StonardPart I: Principles of cellular pathology 1394.1 Structure and function of normal cells, tissues and organs 1394.2 Tissues and organs 1404.3 Cellular responses to injury 1414.4 Tissue responses to injury: acute inflammation 1434.5 Tissue responses to injury: chronic inflammation 1494.6 Healing and repair 1514.7 Hyperplasia and hypertrophy 1544.8 Atherosclerosis 1554.9 Thrombosis and embolism 1574.10 Ischaemia and infarction 1594.11 Amyloid and amyloidosis 1604.12 Infections of histological importance 1624.13 Metaplasia, dysplasia and carcinoma in situ 1654.14 Neoplasia 168Part II: Clinical application and laboratory techniques 1754.15 Sampling modalities 1754.16 Fixation 1784.17 Specimen dissection 1804.18 Processing and embedding 1824.19 Microtomy 1844.20 Standard staining methods and procedures 1864.21 Frozen section 1904.22 Immunohistochemistry 1914.23 Cytopathology 1964.24 Electron microscopy 1974.25 In situ hybridization 201Bibliography 203Chapter 5 Clinical chemistry 205 Ray K. Iles and Stephen A. ButlerIntroduction 205Part I: Analytical methods 2055.1 Sample collection 2055.2 Analytical methods in clinical chemistry laboratories 2105.3 Summary: common clinical tests for sample analytes 231Part II: Clinical assessments 2325.4 Urea and electrolytes (U and Es) 2325.5 Metabolism and gastrointestinal markers 2345.6 Renal function tests 2365.7 Liver function tests 2375.8 Heart disease and lipid disorder tests 2385.9 Pancreatic function tests 2405.10 Bone disease assessment 2415.11 Endocrinological assessments 2415.12 Pregnancy tests and pregnancy clinical chemistry 2495.13 Therapeutic drug monitoring and toxicology 2515.14 Clinical chemistry at the extremes of age 2535.15 Cancer biomarkers 254Bibliography 259Chapter 6 Medical microbiology 261Sarah J. Furrows and Catherine S. FontinelleIntroduction 2616.1 Overview of microorganisms 2616.2 Laboratory investigation of infection 2656.3 Bacteria 2776.4 Fungi 2846.5 Parasitology --- protozoa and helminths 2886.6 Viruses 2906.7 Prions 2976.8 Infections in the immunocompromised patient 2986.9 Healthcare associated infections 2996.10 Antimicrobial agents 3026.11 Vaccines 3076.12 Conclusion 309Bibliography 309Chapter 7 Clinical immunology 311Ray K. Iles and Ivan M. RoittPart I: The fundamentals of immunology 3117.1 Overview of the immune system 3117.2 Overview of the immune response 3167.3 MHC genotyping, autoimmunity and susceptibility to disease 3217.4 Physical age and immunocompetency 322Part II: Laboratory investigations and immune assessments 3237.5 Inflammation and chronic infection 3237.6 Autoimmune diseases 3247.7 Transplant rejection 3257.8 Hypersensitivities 3267.9 Immune deficiency 326Bibliography 328Chapter 8 Haematology and transfusion science 329Suzanne M. Docherty8.1 Introduction and components of blood 3298.2 Routine laboratory blood tests 3328.3 Haemopoiesis 3368.4 Red blood cell structure, disorders and metabolism 3378.5 Haemoglobin 3428.6 Anaemia 3538.7 Benign white blood cell disorders 3598.8 Haemostasis 3618.9 Coagulation disorders 3668.10 Myeloproliferative disorders 3718.11 Haematological malignancies 3738.12 Complement 3788.13 Blood transfusion 3808.14 Blood products 3908.15 Haemopoetic stem cell transplantation 393Bibliography 395Chapter 9 Professional practice and biomedical science 397David Ricketts9.1 What is a biomedical scientist? 3979.2 The IBMS 3979.3 Professional practice and the role of the HPC 3989.4 Standards of proficiency --- biomedical scientists 3999.5 Expectations of a health professional 4009.6 Professional relationships 4019.7 The skills required for the application of practice 4019.8 Knowledge, understanding and skills 4029.9 Standards of conduct, performance and ethics 4039.10 Cpd 4039.11 Critical reflection 4049.12 IBMS CPD scheme 4049.13 The professional biomedical scientist as an agent for change in the wider healthcare setting 405Appendix 407Index 413

“As an accompaniment to an undergraduate programme, this is an excellent text that manages to introduce all aspects of biomedical science to the reader.”  (British Journal of Biomedical Science, 1 January 2013)“Overall, Biomedical Sciences: Essential Laboratory Medicine would make a fantastic starting textbook for biomedical students.  It is accessible, clinically-focused and covers all major relevant topics.  (Phenotype, 28 May 2012)