Biomarkers

VISHAL S. VAIDYA, PHD, is an Assistant Professor of Medicine at Harvard Medical School in the Renal Division of Brigham and Women's Hospital. He directs the Laboratory of Kidney Toxicology and Regeneration with a research emphasis on discovery and evaluation of biomarkers and biosensors for early detection of kidney injury and investigates the molecular mechanisms of kidney tissue repair. Dr. Vaidya has authored more than thirty-five original research articles and twelve chapters and reviews. He serves as a councilor for the northeast chapter of the Society of Toxicology and is an elected member of Harvard School of Public Health's Center for Environmental Health. He is the recipient of the Pathway to Independence grant by the National Institute of Environmental Health Sciences. JOSEPH V. BONVENTRE, MD, PHD, is the Samuel A. Levine Professor of Medicine at Harvard Medical School. He is also Chief of the Renal Division and Director of the Biomedical Engineering Division of Brigham and Women's Hospital and is President-elect of the American Society of Nephrology. He has authored more than 250 original papers and 120 chapters and reviews. His research focuses primarily on the study of kidney injury and repair and signal transduction, with special emphasis on the role of inflammation, biomarkers, and stem cells. Bonventre has received a MERIT award from the National Institute of Diabetes and Digestive and Kidney Diseases.

• Preface xxiiContributors xxv1 Biomarkers: An Evolutionary Perspective 1Michael Ferguson and Vishal VaidyaSection I: Tools for Biomarker Discovery 52 Genomics 7Weida Tong and Donna L. Mendrick3 Proteomics for Biomarker Discovery 25Timothy D. Veenstra4 Metabolic Profiling for Biomarker Discovery 47Hector C. Keun5 The Bittersweet Promise of Glycobiology 75Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya SenguptaSection II: Biomarkers of Injury/Disease 896 Biomarkers of Alzheimer's and Parkinson's Disease 91 Walter Maetzler and Daniela Berg7 Biomarkers of Cardiac Injury 119Anthony S. McLean and Stephen J. Huang8 Lung Injury Biomarkers 157Urmila P. Kodavanti9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah10 Biomarkers of Acute Kidney Injury 237Frank Dieterle and Frank Sistare11 In Search of Biomarkers for Drug-Induced Vascular Injury 281James R. Turk12 Biomarkers of Immunotoxicity 307Rodney R. Dietert13 Biomarkers in Obstetric Medicine 323Manish Maski, Sarosh Rana and S. Ananth Karumanchi14 Biomarkers in Cancer 355 Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses15 Biomarkers of HIV 381Lewis Kaufman and Michael J Ross16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401James A. Dykens and Yvonne WillSection III: Technology for Biomarker Detection 42317 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425Vincent Ricchiuti18 Nanoscale Techniques for Biomarker Quantification 457Madhukar Varshney, and Harold G. Craighead19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. MefferdSection IV: Hot Topics In Biomarker Research 51720 Biomarkers for Environmental Exposure 519Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards21 Clinical Study Design in Biomarker Research 549Orfeas Liangos and Bertrand L. Jaber22 Statistical Issues in Biomarker Research 561Daniel Holder and Matthew Schipper23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581Federico Goodsaid24 The European Medicines Agency Approach 589Marisa Papaluca Amati and Spiros VamvakasIndex 595

"In summary, this book provides an excellent introduction and overview of discovery and application of biomarkers in medicine and drug discovery and development. The chapters are well structured, with plenty of literature references for further reading, and supplemented with links to web-based resources." (ChemMedChem, 2011) "They cover tools for discovering biomarkers, biomarkers for injury or disease, technology for detecting biomarkers, and hot topics in biomarker research." (SciTech Book News, December 2010)"This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers." (News Blaze, 1 November 2010)