This book provides a comprehensive review of novel adaptive trial designs for targeted therapies and immunotherapies. This book covers a wide range of novel statistical designs for various clinical settings, including early phase dose-escalation study, proof-of-concept trials, and confirmatory studies with registrational.
Introduction to Adaptive Design and Delayed Outcomes.- Basics of Bayesian Statistics.- Phase I Dose-finding Design.- Phase II Design for Interim Monitoring.- Phase I-II Dose-finding Design.- Drug Combination Trial Design.- Conclusion.
Ying Yuan, Ruitao Lin, J. Jack Lee, USA) Yuan, Ying (University of Texas, USA) Lin, Ruitao (University of Texas, USA) Lee, J. Jack (University of Texas
Ying Yuan, Hoang Q. Nguyen, Peter F. Thall, USA) Yuan, Ying (University of Texas, USA) Nguyen, Hoang Q. (the University of Texas MD Anderson Cancer Center, Houston, USA) Thall, Peter F. (M.D. Anderson Cancer Center, Houston, Texas, Hoang Q Nguyen, Peter F Thall