Basic Virology

MARTINEZ J. HEWLETT is Professor Emeritus in the Department of Molecular and Cellular Biology at the University of Arizona.DAVID CAMERINI is Assistant Professor in the Department of Molecular Biology and Biochemistry at the University of California Irvine.DAVID C. BLOOM is Associate Professor in the Department of Molecular Genetics and Microbiology at University of Florida.

• Preface xxiAcknowledgements xxviiPart I Virology and Viral Disease 1Chapter 1 Introduction – The Impact of Viruses on Our View of Life 3Chapter 2 An Outline of Virus Replication and Viral Pathogenesis 15Chapter 3 Virus Disease in Populations and Individual Animals 27Chapter 4 Patterns of Some Viral Diseases of Humans 43Part II Basic Properties of Viruses and Virus–cell Interaction 65Chapter 5 Virus Structure and Classification 67Chapter 6 The Beginning and End of the Virus Replication Cycle 85Chapter 7 The Innate Immune Response: Early Defense Against Pathogens 105Chapter 8 Strategies to Protect Against and Combat Viral Infection 131Part III Working with Virus 153Chapter 9 Visualization and Enumeration of Virus Particles 155Chapter 10 Replicating and Measuring Biological Activity of Viruses 163Chapter 11 Physical and Chemical Manipulation of the Structural Components of Viruses 181Chapter 12 Characterization of Viral Products Expressed in the Infected Cell 197Chapter 13 Viruses Use Cellular Processes to Express their Genetic Information 217Part IV Replication Patterns of Specific Viruses 245Chapter 14 Replication of Positive‐Sense RNA Viruses 247Chapter 15 Replication Strategies of RNA Viruses Requiring RNA‐directed mRNA Transcription as the First Step in Viral Gene Expression 277Chapter 16 Replication Strategies of Small and Medium‐sized DNA Viruses 307Chapter 17 Replication of Some Nuclear‐replicating Eukaryotic DNA Viruses with Large Genomes 335Chapter 18 Replication of Cytoplasmic DNA Viruses and “Large” Bacteriophages 363Chapter 19 Retroviruses: Converting RNA to DNA 385Chapter 20 Human Immunodeficiency Virus Type 1 (HIV‐1) and Related Lentiviruses 403Chapter 21 Hepadnaviruses: Variations on the Retrovirus Theme 415Part V Molecular Genetics of Viruses 437Chapter 22 The Molecular Genetics of Viruses 439Chapter 23 Molecular Pathogenesis 467Chapter 24 Viral Bioinformatics 477Chapter 25 Viruses and the Future – Problems and Promises 489Appendix – Resource Center 503Technical Glossary 509Index 533