Autophagy Processes and Mechanisms

Rohan Dhiman is Associate Professor in the Department of Life Science at Rourkela, Odisha, India. He completed his Ph.D. at Institute of Microbial Technology, Chandigarh before moving to University of Texas Health Science Centre at Tyler for post-doctorate training. After four years there with virulent mycobacteria to study the role of NK cells, regulatory T-cells and monocyte heterogeneity in tuberculosis, he returned to India and joined as a Research Scientist in Translational Health Science and Technology Institute where he started studying different facets of pathways related to autophagy and post-translational modification regulated by mycobacterium in infected macrophages. After joining in current institute in 2014, he started his independent lab and currently focusing on screening some libraries w.r.t. autophagy induction ability of the molecules and Calcimycin is one of the compounds that his lab found through this approach. He has published 35 papers till now and co-authored different book chapters. Sujit Kumar Bhutia is currently working as an Associate Professor at the Department of Life Science, National Institute of Technology in Rourkela, India. He received his doctorate in cell biology and cancer from the Indian Institute of Technology, Kharagpur, India in 2008, and subsequently pursued post-doctoral research on autophagy and cancer at Virginia Commonwealth University, USA. His research interests are focused on understanding the role of autophagy and autophagy-dependent cell death in cancer for the development of novel therapeutics. He has published more than 90 research articles in international peer-reviewed journals and authored or co-authored numerous books and book chapters. He is also serving as a referee for several international journals. Dr. Bhutia has more than 10 years of teaching experience in the areas of cell biology, cell signaling, cancer biology, and cell death.

• 1. mTOR signalling and autophagy regulation 2. AMPK signalling in autophagy induction 3. ATG1/ULK1 complex in autophagy 4. Beclin-1-associated complex in autophagy and regulation   5. Autophagy conjugation system in autophagy6. ATG8 family protein, cargo selection and autophagy 7. Mechanism of autophasosome and lysosomal fusion in autophagy 8. Lysosome in autophagy induction and cellular homeostasis 9. Autophagic lysosmal reformation: the beginning from end10. Lipid in membrane formation for autophagosome and autophagy induction11. Implication of autophagy in health, diseases and aging 12. Detection and experimental analysis of autophagy and processes for future research applications