Autophagy, Infection, and the Immune Response

The relationship between infection and immunity and autophagy, a pathway of cellular homeostasis and stress response,has beena rapidly growing field of study over the last decade. While some cellular processes are pro- or anti-infection, autophagy has been proven to be both: a part of the innate immune response against some microbes, and a cellular pathway subverted by some pathogens to promote their own replication. Autophagy, Infection, and the Immune Responseprovides a unified overview of the roles of cellular autophagy during microbial infection. Introductory chaptersground the reader by delineating theautophagic pathway froma cellular perspective,and by listing assays available for measuring autophagy. Subsequent chaptersaddress virus interactions with autophagy machinery, the various roles of autophagy parasitic infection, and interactions of bacteria with the autophagic pathway.Concluding chaptersexplore the relationships of autophagy to systemic immune responses, including antigen presentation, ER stress, and production of IFN-gamma. Designed as a resource for those interested in initiating studieson the relationship between autophagy and infection or immunity, Autophagy, Infection, and the Immune Responsecombines practical state-of the art technique descriptions with an overview of the wide variety of known interactions between pathogens and the autophagic pathway.