The U.S. Environmental Protection Agency (EPA) has been considering a more stringent regulation of arsenic in water. A significant reduction in the maximum contaminant level (MCL) could increase compliance costs for water utilities. This book discusses the adequacy of the current EPA MCL for protecting human health in the context of stated EPA policy and provides an unbiased scientific basis for deriving the arsenic standard for drinking water and surface water. Arsenic in Drinking Water evaluates epidemiological data on the carcinogenic and noncarcinogenic health effects of arsenic exposure of Taiwanese populations and compares those effects with the effects of arsenic exposure demonstrated in other countriesa "including the United States. The book also reviews data on toxicokinetics, metabolism, and mechanism and mode of action of arsenic to ascertain how these data could assist in assessing human health risks from arsenic exposures. This volume recommends specific changes to improve the toxicity analyses and risk characterization. The implications of the changes for EPAa (TM)s current MCL for arsenic are also described.
Subcommittee on Arsenic in Drinking Water, National Research Council
1 Front Matter; 2 Executive Summary; 3 1 Introduction; 4 2 The U.S. Environmental Protection Agency's 1988 Risk Assessment for Arsenic; 5 3 Chemistry and Analysis of Arsenic Species in Water and Biological Materials; 6 4 Health Effects of Arsenic; 7 5 Disposition of Inorganic Arsenic; 8 6 Biomarkers of Arsenic Exposure; 9 7 Mechanisms of Toxicity; 10 8 Variation in Human Sensitivity; 11 9 Essentiality and Therapeutic Uses; 12 10 Statistical Issues; 13 11 Risk Characterization; 14 Addendum to Chapter 9; 15 Addendum to Chapter 10
National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Metagenomics: Challenges and Functional Applications
National Research Council, Division of Behavioral and Social Sciences and Education, Institute of Medicine, and Families Board on Children, Youth, Steve Olson
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Animal Nutrition, Subcommittee on Dog and Cat Nutrition
National Research Council, Division on Earth and Life Studies, Board on Agriculture and Natural Resources, Committee on Nutrient Requirements of Horses
National Research Council, Division of Behavioral and Social Sciences and Education, Commission on Behavioral and Social Sciences and Education, and Statistical Sciences Committee on AIDS Research and the Behavioral, Social, Lincoln E. Moses, Heather G. Miller, Charles F. Turner
National Research Council, Division on Engineering and Physical Sciences, and Applications Commission on Physical Sciences, Mathematics, Committee to Provide Interim Oversight of the DOE Nuclear Weapons Complex
National Research Council, Division on Earth and Life Studies, Environment and Resources Commission on Geosciences, Board on Environmental Studies and Toxicology, Committee to Review the Outer Continental Shelf Environmental Studies Program, Ecology Panel
National Research Council, Division on Engineering and Physical Sciences, Commission on Engineering and Technical Systems, Committee on Alternative Chemical Demilitarization Technologies
National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee to Update the 1999 Arsenic in Drinking Water Report