Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Munther Khamashta is Professor/Consultant Physician and Director of The Graham Hughes Lupus Research Laboratory at St Thomas’ Hospital, London, and runs a large lupus pregnancy clinic. He studied medicine in Barcelona and internal medicine in Madrid, Spain, where he developed an interest in connective tissue diseases and received his PhD. He was awarded the MRCP in 1999 and FRCP in 2002. He joined the Lupus Unit in London 25 years ago and has been instrumental in developing it into an internationally recognised tertiary centre receiving referrals from all over the UK, see https://kclpure.kcl.ac.uk/portal/en/persons/munther-khamashta(e30b3284-8df1-4cc2-9856-9bca61db843e)/biography.html Gerard Espinosa, MD, PhD is Consultant at the Department of Autoimmune Diseases, Hospital Clínic, Barcelona, member of the Research Team on Systemic Autoimmune Diseases (coordinator of the Clinical Trials Unit) at the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona and Associate Professor at the Department of Medicine, Universitat de Barcelona, Barcelona, Catalonia, Spain.

• 1. History, Classification, and Subsets of the Antiphospholipid Syndrome2. Epidemiology of the Antiphospholipid Syndrome3. Mechanisms of Action of the Antiphospholipid Antibodies4. Laboratory Markers With Clinical Significance in the Antiphospholipid Syndrome5. Genetic and Epigenetic Aspects of Antiphospholipid Syndrome: What we knew, what we know6. Thrombotic Manifestations of the Antiphospholipid Syndrome7. Obstetric Manifestations of the Antiphospholipid Syndrome8. Thrombocytopenia in the Antiphospholipid Syndrome9. Nonclassification Criteria Manifestations of the Antiphospholipid Syndrome10. Paediatric Antiphospholipid Syndrome11. Antiphospholipid Antibodies and Their Relationship With Infections, Vaccines, and Drugs12. Antiphospholipid Syndrome Associated With Malignancies13. Antiphospholipid Antibodies and Atherosclerosis14. Global Antiphospholipid Syndrome Score15. Primary Prophylaxis in Patients With Positive Antiphospholipid Antibodies16. Treatment of Thrombosis in Antiphospholipid Syndrome17. Treatment of Catastrophic Antiphospholipid Syndrome18. Treatment of Pregnancy Complications in Antiphospholipid Syndrome19. Prognosis in Antiphospholipid Syndrome