Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines: * The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome. * The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura.The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.
Christopher P. Howson, Cynthia J. Howe, and Harvey V. Fineberg, Editors;Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines, Institute of Medicine
Front Matter1 Executive Summary2 Histories of Pertussis and Rubella Vaccines3 Methodologic Considerations in Evaluating the Evidence4 Evidence Concerning Pertussis Vaccines and Central Nervous System Disorders, Including Infantile Spasms, Hypsarrhythmia, Aseptic Meningitis, and Encephalopathy5 Evidence Concerning Pertussis Vaccinces and Deaths Classified as Sudden Infant Death Syndrome (SIDS)6 Evidence Concerning Pertussis Vaccines and Other Illnesses and Conditions7 Evidence Concerning Rubella Vaccines and Arthritis, Radiculoneuritis, and Thrombocytopenic PurpuraAfterword on Research NeedsBibliographyGlossary of TermsAppendix A: Strategies for Gathering Information: Adverse Effects of Pertussis and Rubella VaccinesAppendix B: Pertussis and Rubella Vaccines: A Brief ChronologyAppendix C: Animal Models for the Study of Whooping Cough and the Testing of Vaccine MaterialsAppendix D: Technical Details of Power Calculations and Meta-AnalysesAppendix E: Possible Involvement of Aluminum Salts in Erythema Multiforme, Encephalopathy, or Other Adverse Events After Pertussis ImmunizationAppendix F: Committee and Staff BiographiesIndex
National Research Council, Division of Behavioral and Social Sciences and Education, Institute of Medicine, and Families Board on Children, Youth, Steve Olson
Institute of Medicine, Board on the Health of Select Populations, and Transgender Health Issues and Research Gaps and Opportunities Committee on Lesbian, Gay, Bisexual
Institute of Medicine, Board on Population Health and Public Health Practice, Division of Health Promotion and Disease Prevention, Division of International Health
Institute of Medicine, Committee to Develop Methods Useful to the Department of Veteran Affairs in Estimating Its Physician Requirements, Joseph Lipscomb
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie McCormick, Padma Shetty, Alicia Gable, Kathleen Stratton
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Theresa Wizemann, Donna A. Alamario, Kathleen Stratton
and Medicine National Academies of Sciences, Engineering, Health and Medicine Division, Board on Population Health and Public Health Practice, Committee on a National Strategy for the Elimination of Hepatitis B and C, Brian L. Strom, Gillian J. Buckley
Institute of Medicine, Division of Health Promotion and Disease Prevention, Committee to Study Priorities for Vaccine Development, Robert S. Lawrence, Jane S. Durch, Kathleen R. Stratton
Institute of Medicine, Division of Health Promotion and Disease Prevention, Committee on the Elimination of Tuberculosis in the United States, Lawrence Geiter
Institute of Medicine, Division of Health Promotion and Disease Prevention, Division of Health Care Services, Committee on Immunization Finance Policies and Practices
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Alicia Gable, Kathleen Stratton
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Christopher B. Wilson, Kathleen Stratton
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Donna A. Almario, Kathleen Stratton
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Alicia Gable, Kathleen Stratton
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Theresa M. Wizemann, Donna A. Almario, Kathleen Stratton
Institute of Medicine, Board on Population Health and Public Health Practice, Committee on the Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie McCormick, Padma Shetty, Alicia Gable, Kathleen Stratton
Institute of Medicine, Board on Global Health, Board on Population Health and Public Health Practice, Phase II Committee on Identifying and Prioritizing New Preventive Vaccines for Development, Lonnie King, Rose Marie Martinez, Rino Rappuoli, Dennis Fryback, Charles Phelps, Kinpritma Sangha, Guruprasad Madhavan
National Academy of Engineering, Institute of Medicine, Board on Global Health, Board on Population Health and Public Health Practice, Phase III Committee on Identifying and Prioritizing New Preventive Vaccines for Development, Lonnie King, Rose Marie Martinez, Rino Rappuoli, Charles Phelps, Guruprasad Madhavan
Institute of Medicine, Board on Health Promotion and Disease Prevention, Immunization Safety Review Committee, Marie C. McCormick, Donna A. Almario, Kathleen Stratton
Institute of Medicine, Division of Health Promotion and Disease Prevention, Division of Health Care Services, Committee on Immunization Finance Policies and Practices