ABC Transporters - 40 Years on

Assoc Prof A M George School of Medical & Molecular Biosciences Institute for Biotechnology of Infectious Diseases Faculty of Science University of Technology Sydney PO Box 123 Broadway NSW 2007 Australia Tel: +61 2 9514 4158 Fax: +61 2 9514 8206 Email: tony.george@uts.edu.au

• ABC Importers.- Inborn errors and potential correction of the cellular expression and localization of medically important ABC transporters.- Human ABC transporter ABCC11: Molecular mechanistic, pharmacological, and anthropological aspects.- Biology of mitochondrial ABCs and their contribution to pathology.- ABC transporters and multidrug resistance in fungi and yeast.- Structural and mechanistic insights into modulation of P-glycoprotein (ABCB1)function by tyrosine kinase inhibitors.- Techniques for the purification of ABC transporters.- HDAC inhibitors and MDR ABC transporters.- The role of polymorphisms in P-glycoprotein (ABCB1) on function.- Interaction of ABC transporters with drugs.- ABC insights from CFTR.