3D Lung Models for Regenerating Lung Tissue

Häftad, Engelska, 2022

AvGunilla Westergren-Thorsson,Sara Rolandsson Enes,Sweden) Westergren-Thorsson, Gunilla (Professor, Lund University, Lund,Sweden) Enes, Sara Rolandsson (Associated Researcher, Lund University, Lund

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3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition.

Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field.

A comprehensive summary of advanced 3D lung models written by the experts in the respiratory field
Explore novel techniques that can be used to evaluate and improve 3D lung models, including techniques such as 3D printing, bioprinting, and artificial intelligence
Explains what extracellular matrix is, the complexity of the lung microenvironment, and why this knowledge is important for creating a functional bioartificial lung

Produktinformation

Utgivningsdatum2022-08-12
Mått191 x 235 x 18 mm
Vikt540 g
FormatHäftad
SpråkEngelska
Antal sidor260
FörlagElsevier Science
ISBN9780323908719

Tillhör följande kategorier

Lungmedicin inom Medicin

Professor in lung biology with a specific focus on extracellular matrix linked to structural changes and lung function in human chronic lung diseases. During the past decade, her research focus has shifted more towards developing human 3D lung model systems and bioreactors. She was the Dean of the Medical Department at Lund University for 6 years, and one of the chairs of the national board of SciLifeLab, working with infrastructure in Life Science at a national level to facilitate the use and edge of different techniques. Dr. Enes is an associated researcher in lung biology with a specific focus on stem cells and their interactions with the microenvironment. During the recent years, her research focus has been on how the microenvironment affects the biology and function of stem cells and how this knowledge could be applied to improve cell therapy. In 2019, she was involved in putting together and leading a session on the topic “From 2D to 3D models of human lung disease: novel developments to rebuild the lung for the large European Respiratory Society (ERS) annual congress. In addition, she was invited to write a landmark paper on bioartificial lungs.

Part I: Standard 2D culture on plastic1. 2D culture on plastic, past, present, important findings and breakthroughs2. The importance of microenvironment (ECM, GAG)Part II: 3D lung models3. ALI model4. Biofilms5. Lung organoid models6. 3D models Artificial material7. 3D extracellular matrix models8. Lung-on-a-chip9. Flow, Mechanical properties, and bioreactors 10. Challenges with 3D models and Future directions Part III: New directions11. 3D printing and bioprinting12. Drug-screening and high throughput in 3D lung models13. Model validation14. AI and computational modelling15. Conclusions