2025 Nelson's Pediatric Antimicrobial Therapy

Debra Palazzi, MD, MEd is Professor of Pediatrics and Division Chief of Pediatric Infectious Diseases at Baylor College of Medicine in Houston, Texas. She is Medical Director of the Antimicrobial Stewardship Program at Texas Children’s Hospital and participates in national antimicrobial stewardship educational and research activities. She has a strong interest in medical education and directed or co-directed pediatric infectious diseases fellowship education at Baylor College of Medicine from 2007-2023. She is the Editor of the American Academy of Pediatrics’ Pediatric Review and Education Program (PREP) for Infectious Diseases and was a planning committee member, then course co-director, of the PREP ID Review Course for a decade. She is an associate editor for JAMA Pediatrics, one of the leading journals in the world for child health. She has been a member of the Pediatric Infectious Diseases Society (PIDS) Board of Directors since 2017 and currently serves as President Elect. Dr. Palazzi focuses on providing unparalleled, personalized, family-centered clinical care to infants, children, and adolescents with suspected or proven infectious diseases.    John S. Bradley, MD, FAAP, has been the Medical Director of the Division of Infectious Diseases at Rady Children's Hospital-San Diego since 1988, and is currently Distinguished Professor of Pediatrics, Division of Infectious Diseases, Department of Pediatrics, University of California, San Diego School of Medicine. He has served on the American Academy of Pediatrics Committee on Infectious Diseases (Red Book Committee) 2004-2010, and the Council of the Pediatric Infectious Diseases Society (PIDS) Council, 2007-2011 where he promoted the development of a PIDS Antimicrobial Stewardship program.  John D. Nelson, MD Emeritus is Professor Emeritus of Pediatrics at the University of Texas Southwestern Medical Center and Children's Medical Center, the same institution since he started his career back in 1957. At UT Southwestern he established the first formal Pediatric Infectious Disease fellowship program with Dr. Kenneth Haltalin and later Dr. George McCracken. He also went on to establish the National Pediatric Infectious Disease Seminar with Dr. McCracken and in 1982 they founded the Pediatric Infectious Disease Journal for which they continue as Chief Editors. In 1975 Dr. Nelson produced the first edition of the Pocket Book of Pediatric Antimicrobial Therapy which has gone through 20 biennial editions and is now edited by Dr. John Bradley.

• IntroductionAbbreviationsNotable Changes to 2025 Nelson’s Pediatric Antimicrobial Therapy, 31st EditionAntimicrobial Therapy According to Clinical SyndromesAntimicrobial Therapy for NeonatesPreferred Therapy for Specific Bacterial and Mycobacterial PathogensChoosing Among Antibiotics Within a Class: B-Lactams and B-Lactamase Inhibitors, Macrolides, Aminoglycosides, and FluoroquinolonesPreferred Therapy for Specific Fungal PathogensChoosing Among Antifungal Agents: Polyenes, Azoles, and EchinocandinsPreferred Therapy for Specific Viral PathogensChoosing Among Antiviral AgentsPreferred Therapy for Specific Parasitic PathogensChoosing Among Antiparasitic Agents: Antimalarial Drugs, Nitroimidazoles, Benzimidazoles, and Neglected Tropical DiseasesHow Antibiotic Dosages Are Determined by Susceptibility Data, Pharmacodynamics, and Treatment OutcomesApproach to Antibiotic Therapy for Drug-Resistant Gram-Negative Bacilli and Methicillin-Resistant Staphylococcus aureusAntibiotic Therapy for Children With ObesitySequential Parenteral-Oral Antibiotic Therapy (Oral Step-Down Therapy) for Serious InfectionsAntimicrobial Prophylaxis/Prevention of Symptomatic InfectionApproach to Antibiotic AllergiesAntibiotic StewardshipSystemic and Topical Antimicrobial Dosing and Dose FormsAppendix: Nomogram for Determining Body Surface AreaReferencesIndex