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Harry Baker and Rosalind Ridley have done an admirable job in assem bling this collection of articles that describe the methodology frequently used to study a group of CNS illnesses often referred to as the "prion diseases."
The Paradox of Prion Disease.- Human Spongiform Encephalopathy.- Neuropathological Diagnosis of Human Prion Disease.- Neuropathological Diagnosis of Human Prion Disease.- The Diagnosis of Bovine Spongiform Encephalopathy and Scrapie by the Detection of Fibrils and the Abnormal Protein lsoform.- Exposure to, and Inactivation of, the Unconventional Agents that Cause Transmissible Degenerative Encephalopathies.- Surveillance of Prion Diseases in Humans.- Environmental Causes of Human Spongiform Encephalopathy.- Bovine Spongiform Encephalopathy.- Handling the BSE Epidemic in Great Britain.- Special Problems of Genetic Counseling in Adult-Onset Diseases.- Genotyping and Susceptibility of Sheep to Scrapie.- Strain Typing Studies of Scrapie and BSE.- PrP-Deficient Mice in the Study of Transmissible Spongiform Encephalopathies.- Transgenic Approaches to Prion “Species-Barrier” Effects.- Methods for Studying Prion Protein Amyloid.- Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems.- Immunohistochemistry of Resinated Tissues for Light and Electron Microscopy.
Prion Diseases is a timely publication...Scientists already established in the subject as well as those embarking on such research for the first time will find the book useful. I also recommend it as a well structured text..-British Medical Journal
