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This text provides a treatment of the involvement of plasma membrane redox reactions in the origin and development of biological stress and disease. Thirteen chapters, provided by invited specialists, cover the role of plasma membrane redox systems in cell defence (of plant and animal cells), growth control, antioxidative defence reactions, development of tumour cells, entry of toxins and viruses, reduction and uptake of iron and nitrate, and development of atherosclerosis. Each of these chapters deals extensively with the most recent molecular and cell biological developments in these topics, thereby providing new insights and hypotheses on the mechanisms of action. Overview chapters on the nature and molecular properties of redox proteins identified at the plasma membrane of animal, plant and fungal cells are also included.
Plasma membrane b-type cytochromes.- NAD(P)H-utilizing flavo-enzymes in the plant plasma membrane.- Components and organisation of the NADPH oxidase of phagocytic cells, the paradigm for an electron transport chain across the plasma membrane.- Plasma membrane-bound nitrate reductase in algae and higher plants.- NADH oxidase: a multifunctional ectoprotein of the eukaryotic cell surface.- Iron transport in yeast: the involvement of an iron reductase and oxidase.- Reduction and uptake of iron in plants.- Involvement of plasma membrane redox systems in growth control of animal and plant cells.- Possible sources of reactive oxygen during the oxidative burst in plants.- Antioxidative role of ubiquinone in animal plasma membrane.- Metal reduction by macrophages: Its role in low-density lipoprotein oxidation.- Plasma membrane protein disulfide isomerase: its role in the translocation of diphtheria toxin and HIV virus across endosomal and cell membranes.- Plasma membrane redox systems in tumor cells.
'This is an outstanding collection of reviews... I did not find a single chapter disappointing. Moreover, it was clearly edited and produced extremely efficiently... extensive referencing... I strongly recommend the book to all who seek a solid grounding in this fascinating field.' Antioxidants & Redox Signaling, 2:2 (2000)