Oxygen Biology and Hypoxia

Helmut Sies, MD, PhD (hon), studied medicine at the universities of Tübingen, Munich, and Paris. He was the professor and chair of the Institute for Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf, Germany, where he is now professor emeritus. He is a member of the German National Academy of Sciences Leopoldina and was the president of the North Rhine-Westphalian Academy of Sciences and Arts. He was named ‘Redox Pioneer’; was the president of the Society for Free Radical Research International (SFRRI). Helmut Sies introduced the concept of “Oxidative Stress” in 1985, and was the first to reveal hydrogen peroxide as a normal constituent of aerobic cell metabolism. His research interests comprise redox biology, oxidants, antioxidants, micronutrients.

• Section I. Hypoxia-inducible factor Chapter 1HIF PAS domains: structure and function Thomas H. Scheuermann, Jinsong Yang, Lei Zhang, Kevin H. Gardner, and Richard K. BruickChapter 2Structure-function analysis of HIFLorenz Poellinger Chaper 3HIF Prolyl Hydroxylase: Purification and Assays of PHD2Kirsty S. Hewitson, Christopher J. Schofield, Peter J. RatcliffeChapter 4Determination and modulation of prolyl-4-hydroxylase domain (PHD) oxygen sensor activityRenato Wirthner, Kuppusamy Balamurugan, Daniel P. Stiehl, Sandra Barth, Patrick Spielmann, Felix Oehme, Ingo Flamme, Dörthe M. Katschinski, Roland H. Wenger and Gieri CamenischChapter 5Characterisation of ankyrin-repeat containing proteins as substrates of the asparaginyl hydroxylase Factor Inhibiting HIF (FIH-1).Sarah Linke, Rachel J. Hampton-Smith, Daniel J. PeetChapter 6Transgenic Models to Understand HIF FunctionAndrew Doedens and Randall S. JohnsonChapter 7The Silencing Approach of the Hypoxia Signalling Pathway"Edurne Berra and Jacques PouyssegurChapter 8Cellular and developmental adaptations to hypoxia; a Drosophila perspectiveNuria Magdalena Romero, Andrés Dekanty, Pablo WappnerSection II. Erythropoietin Chapter 9Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligationGiovanni G. Camici, Thomas Stallmach, Matthias Hermann, Rutger Hassink, Peter Doevendans, Beat Grenacher, Alain Hirschy, Johannes Vogel, Thomas F. Lüscher, Frank Ruschitzka and Max GassmannChapter 10Control of erythropoietin gene expression and its use in medicineWolfgang JelkmannChapter 11Role of HIF-2 in endothelial development and hematopoiesisOsamu Ohneda1,3, Masumi Nagano1,3 and Yoshiaki Fujii-KuriyamaSection III. Hypoxia and adaptationChapter 12ORGAN PROTECTION BY HYPOXIA AND HIFWanja M. Bernhardt, Christina Warnecke, Carsten Willam, Michael S. Wiesener and Kai-Uwe EckardtChapter 13Hypoxia and regulation of mRNA translationMarianne Koritzinsky and Bradly G. WoutersChapter 14Hypoxia and the Unfolded Protein ResponseConstantinos Koumenis, Meixia Bi, Jiangbin Ye, Douglas Feldman and Albert C. KoongSection IV. Hypoxia and tumor biologyChapter 15Tumor hypoxia in cancer therapyJ. Martin BrownChapter 16HIF Gene Expression in Cancer TherapyBy Denise A. Chan, Adam J. Krieg, Sandra Turcotte, and Amato J. GiacciaChapter 17Analysis of HIF-1 Expression and Its Effects on Invasion and MetastasisBalaji Krishnamachary, Gregg L. Semenza Chapter 18Macrophage migration inhibitory factor (MIF) manipulation and evaluation in tumoral hypoxic adaptationMillicent Winner, Lin Leng, Wayne Zundel and Robert A. MitchellChapter 19The von Hippel-Lindau Tumor Suppressor Protein: An UpdateWilliam G. Kaelin, Jr.Chapter 20Hypoxia Inducible Factor 1 (HIF-1) inhibitorsGiovanni MelilloSection V. Hypoxia and inflammatory mediatorsChapter 21Regulation of HIF during InflammationStilla Frede, Utta Berchner-Pfannschmidt, Joachim FandreyChapter 22Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factorsAgnes Görlach, Thomas KietzmannChapter 23Genetics of mitochondrial electron transport chain in regulating oxygen sensingEric L. Bell and Navdeep S. ChandelChapter 24Hypoxia inducible factor-1 (HIF-1) under the control of nitric oxide (NO) Bernhard Brüne and Jie ZhouChapter 25Hypoxic regulation of NF-κB signallingEoin P. Cummins, Katrina M. Comerford, Carsten Scholz, Ulrike Bruning & Cormac T. Taylor