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The up-to-DATE guide to name reactions in heterocyclic chemistryName Reactions in Heterocyclic Chemistry II presents a comprehensive treatise on name reactions in heterocyclic chemistry, one of the most excitingand importantfields within organic chemistry today.The book not only covers fresh ground, but also provides extensive information on new and/or expanded reactions in: Three- and four-membered heterocycles Five-membered heterocycles (pyrroles and pyrrolidines, indoles, furans, thiophenes, and oxazoles) Six-membered heterocycles, including pyridines, quinolines, and isoquinolines Featuring contributions from the leading authorities in heterocyclic chemistry. Each section includes a description of the given reaction, as well as the relevant historical perspective, mechanism, variations and improvements, synthetic utilities, experimental details, and references to the current primary literature.The reactions covered in Name Reactions in Heterocyclic Chemistry have been widely adopted in all areas of organic synthesis, from the medicinal/pharmaceutical field, to agriculture, to fine chemicals, and the book brings the most cutting-edge knowledge to practicing synthetic chemists and students, along with the tools needed to synthesize new and useful molecules.
Jie Jack Li is a Chemist at Bristol-Myers Squibb Company. He has authored or edited various books, including the first volume of Name Reactions in Heterocyclic Chemistry, Name Reactions for Functional Group Transformations, Name Reactions for Carbocyclic Ring Formations, and several others, all published by Wiley.
Foreword viiiPreface ixContributing Authors xiPart 1 Three- and Four-Membered Heterocycles 1Chapter 1 Aziridines and Epoxides 11.1 Blum Aziridine Synthesis 21.2 Gabriel-Heine Aziridine Isomerization 111.3 Shi Epoxidation 21Part 2 Five-Membered Heterocycles 41Chapter 2 Pyrroles and Pyrrolidines 412.1 Clauson-Kass Pyrrole Synthesis 422.2 Houben-Hoesch Acylation of Pyrroles 532.3 Overman Pyrrolidine Synthesis 602.4 Trofimov Synthesis of Pyrroles 72Chapter 3 Indoles 833.1 Bischler-Möhlau Indole Synthesis 843.2 Borsche-Drechsel Cyclization 913.3 Buchwald-Hartwig Indole Synthesis 1023 .4 Cadogan-Sundberg Indole Synthesis 1123.5 Fukuyama Indole Synthesis 1253.6 Gassman Oxindole Synthesis 1333.7 Larock Indole Synthesis 1433.8 Matinet Dioxindole Reaction 1673.9 Mori-Ban Indole Synthesis 1753.10 Sandmeyer Isatin Synthesis 1873.11 Sommelet-Hauser Rearrangement 1973.12 Stolle Oxindole Synthesis 207Chapter 4 Furans and Ox azoles 2134.1 Nierenstein Reaction 2144.2 Davidson Oxazole Synthesis 2214.3 Fischer Oxazole Synthesis 2254.4 Japp Oxazole Synthesis 2334.5 Schhllkopf Oxazole Synthesis 242Chapter 5 Other Five-Mem be red Heterocycles 2595. L Bamberger Imidazole Cleavage 2605.2 Dimroth Triazole Synthesis 2695.3 Finnegan Tetrazole Synthesis 2785.4 Hantzsch Thiazole Synthesis 2995.5 Huisgen Tetrazole Rearrangement 3095.6 Knorr Pyrazole Synthesis 3175.7 Pechmann Pyrazole Synthesis 327Part 3 Six-Membered Heterocycles 337Chapter 6 Pyridincs 3376.1 Baeyer Pyridine Synthesis 3386.2 Katrizky Pyridine Synthesis 347Chapter 7 Quinolines and Isoquinolines 3517.1 Betti Reaction 3527.2 Bemthsen Acridine Synthesis 3607.3 Lehmstedt-Tanasescu Reaction 3687.4 Niementowski Quinoline Synthesis 3767.5 Povarov Reaction 385Chapter 8 Six-Membered Heterocycles 4018.1 Balaban-Nenitzescu-Praill Reaction 4028.2 Borsche Cinnoline Synthesis 4208.3 Gutknecht Pyrazine Synthesis 4308.4 Niementowski Quinazoline Synthesis 4408.5 Pechmann Coumarin Synthesis 4548.6 Robin son-Schöpf Condensation 4708.7 Simonis Chromone Cyclization 4778.8 Wesseley—Moser Rearrangement 4878.9 Widman-Stoermer Cinnoline Synthesis 4938.10 Wichterle Reaction 497Chapter 9 Miscellaneous Name Reactions 5159.1 ANRORC Mechanism 5169.2 Boulton-Katritzky Rearrangement 5279.3 Chichibabin Animation Reaction 5399.4 Dimroth Rearrangement 5549.5 Hantzsch Synthesis 5919.6 Ortolcva-King Reaction 645Appendixes Appendix 1, Table of Contents for Volume 1: Name Reactions in Heterocyclic Chemistry 651Appendix 2, Table of Contents for Volume 2: Name Reactions for Functional Group Transformations 655Appendix 3, Table of Contents for Volume 3: Name Reactions for Hornolegations-I 657Appendix 4, Table of Contents for Volume 4; Name Reactions for Hornohgations-II 659Appendix 5, Table of Contents for Volume 5: Name Reactions for Ring Formations 661Subject Index 663