Michael D. Randall is Professor of Pharmacology, School of Life Sciences, University of Nottingham

• Preface 7Contributors 8Abbreviations 9How To Use Your Textbook 12About the Companion Website 15Part 1 Cellular Structure and Function1 Cells 16Sebastiaan Winkler2 Organisation of Cell Membranes 18Sebastiaan Winkler3 Cell Organelles 20Sebastiaan Winkler4 Protein Biochemistry 22Fergus Doherty5 Lipid Biochemistry 24Jane Arnold6 Carbohydrate Biochemistry 26Fergus Doherty7 Basic Mechanisms of Drug Action 28Michael D RandallPart 2 Cellular Metabolism8 General Principles of Cellular Metabolism 30Fergus Doherty9 Enzymes 32Michael D Randall10 Central Metabolic Pathways 34Fergus Doherty11 Fat Metabolism 36Fergus Doherty12 Glucose Metabolism 38Fergus Doherty13 Amino Acid Metabolism 40Jane ArnoldPart 3 Molecular and Medical Genetics14 Principles of Molecular Genetics 42Stuart Brown15 DNA and RNA 44Stuart Brown16 Gene Expression 46Stuart Brown17 Medical Genetics 48Stuart BrownPart 4 Nerve and Muscle18 Cell Excitability 50Michael D Randall19 Nervous Conduction 52Michael D Randall20 Synaptic Transmission 54Michael D Randall21 Autonomic Nervous System 56Michael D Randall22 Neuromuscular Transmission 58Michael D RandallPart 5 Respiratory System23 Structure of the Respiratory System 60Siobhan Loughna and Deborah Merrick24 Respiratory Physiology 62Steven Burr25 Gas Transport 64Steven Burr26 Control of Breathing 66Steven Burr27 Acid-Base Physiology 68Steven Burr28 Respiratory Pathophysiology 70Steven BurrPart 6 Cardiovascular System29 Structure of the Cardiovascular System 72Siobhan Loughna and Deborah Merrick30 Cardiac Physiology 74Michael D Randall31 Cardiovascular Physiology 76Michael D Randall32 Blood Pressure 78Michael D Randall33 Blood: 1 80Michael D Randall34 Blood: 2 82Michael D Randall35 Cardiovascular Pathophysiology 84Michael D RandallPart 7 Renal System36 Structure of the Renal System 86Deborah Merrick37 Renal Physiology: Filtration and Tubular Function 88Sue Chan38 Renal Physiology: Loop of Henle 90Sue Chan39 Regulation of Body Fluids 92Sue Chan40 Bladder Function and Dysfunction 94Michael D RandallPart 8 Digestive System41 Structure of the Gastrointestinal System 96Deborah Merrick42 Upper Gastrointestinal Physiology 98Michael D Randall43 Lower Gastrointestinal Physiology 100Michael D Randall44 The Liver 102Michael D RandallPart 9 Endocrine System45 Hypothalamus and Pituitary 104Sue Chan46 Endocrine Pancreas 106Sue Chan47 Thyroid Gland 108Sue Chan48 Adrenal Glands and Steroid Hormones 110Sue ChanPart 10 Reproductive Function49 The Genital System 112Deborah Merrick50 Reproductive Physiology 114Michael D Randall51 Human Embryology 116Deborah MerrickPart 11 Central Nervous System52 Structure of the Central Nervous System 118Deborah Merrick53 The Sensory System 120Deborah Merrick54 The Motor System 122Deborah Merrick55 Hypothalamus and Thalamus 124Deborah Merrick56 Central Nervous System Function 126Michael D Randall57 CNS Disorders and Treatments 128Michael D RandallPart 12 Infections and Immunity58 Pathogens 130James Lazenby And Chien-Yi Chang59 Recognition of Pathogens 134Lucy Fairclough and Ian Todd60 Defence Against Pathogens 136Lucy Fairclough and Ian Todd61 Integration of the Immune Response 138Lucy Fairclough and Ian Todd62 Immunopathology 140Ian Todd and Lucy Fairclough63 Immunodeficiency Disorders 142Ian Todd and Lucy FaircloughPart 13 Cancer64 Cancer 145Stuart Brown65 Chemotherapy 148Michael D RandallAppendix 1 Cross References to Medicine at a Glance (Davey) 150Index 154

Select Guide Rating

Michael D. Randall is Professor of Pharmacology, School of Life Sciences, University of Nottingham

• Preface 7Contributors 8Abbreviations 9How To Use Your Textbook 12About the Companion Website 15Part 1 Cellular Structure and Function1 Cells 16Sebastiaan Winkler2 Organisation of Cell Membranes 18Sebastiaan Winkler3 Cell Organelles 20Sebastiaan Winkler4 Protein Biochemistry 22Fergus Doherty5 Lipid Biochemistry 24Jane Arnold6 Carbohydrate Biochemistry 26Fergus Doherty7 Basic Mechanisms of Drug Action 28Michael D RandallPart 2 Cellular Metabolism8 General Principles of Cellular Metabolism 30Fergus Doherty9 Enzymes 32Michael D Randall10 Central Metabolic Pathways 34Fergus Doherty11 Fat Metabolism 36Fergus Doherty12 Glucose Metabolism 38Fergus Doherty13 Amino Acid Metabolism 40Jane ArnoldPart 3 Molecular and Medical Genetics14 Principles of Molecular Genetics 42Stuart Brown15 DNA and RNA 44Stuart Brown16 Gene Expression 46Stuart Brown17 Medical Genetics 48Stuart BrownPart 4 Nerve and Muscle18 Cell Excitability 50Michael D Randall19 Nervous Conduction 52Michael D Randall20 Synaptic Transmission 54Michael D Randall21 Autonomic Nervous System 56Michael D Randall22 Neuromuscular Transmission 58Michael D RandallPart 5 Respiratory System23 Structure of the Respiratory System 60Siobhan Loughna and Deborah Merrick24 Respiratory Physiology 62Steven Burr25 Gas Transport 64Steven Burr26 Control of Breathing 66Steven Burr27 Acid-Base Physiology 68Steven Burr28 Respiratory Pathophysiology 70Steven BurrPart 6 Cardiovascular System29 Structure of the Cardiovascular System 72Siobhan Loughna and Deborah Merrick30 Cardiac Physiology 74Michael D Randall31 Cardiovascular Physiology 76Michael D Randall32 Blood Pressure 78Michael D Randall33 Blood: 1 80Michael D Randall34 Blood: 2 82Michael D Randall35 Cardiovascular Pathophysiology 84Michael D RandallPart 7 Renal System36 Structure of the Renal System 86Deborah Merrick37 Renal Physiology: Filtration and Tubular Function 88Sue Chan38 Renal Physiology: Loop of Henle 90Sue Chan39 Regulation of Body Fluids 92Sue Chan40 Bladder Function and Dysfunction 94Michael D RandallPart 8 Digestive System41 Structure of the Gastrointestinal System 96Deborah Merrick42 Upper Gastrointestinal Physiology 98Michael D Randall43 Lower Gastrointestinal Physiology 100Michael D Randall44 The Liver 102Michael D RandallPart 9 Endocrine System45 Hypothalamus and Pituitary 104Sue Chan46 Endocrine Pancreas 106Sue Chan47 Thyroid Gland 108Sue Chan48 Adrenal Glands and Steroid Hormones 110Sue ChanPart 10 Reproductive Function49 The Genital System 112Deborah Merrick50 Reproductive Physiology 114Michael D Randall51 Human Embryology 116Deborah MerrickPart 11 Central Nervous System52 Structure of the Central Nervous System 118Deborah Merrick53 The Sensory System 120Deborah Merrick54 The Motor System 122Deborah Merrick55 Hypothalamus and Thalamus 124Deborah Merrick56 Central Nervous System Function 126Michael D Randall57 CNS Disorders and Treatments 128Michael D RandallPart 12 Infections and Immunity58 Pathogens 130James Lazenby And Chien-Yi Chang59 Recognition of Pathogens 134Lucy Fairclough and Ian Todd60 Defence Against Pathogens 136Lucy Fairclough and Ian Todd61 Integration of the Immune Response 138Lucy Fairclough and Ian Todd62 Immunopathology 140Ian Todd and Lucy Fairclough63 Immunodeficiency Disorders 142Ian Todd and Lucy FaircloughPart 13 Cancer64 Cancer 145Stuart Brown65 Chemotherapy 148Michael D RandallAppendix 1 Cross References to Medicine at a Glance (Davey) 150Index 154

Select Guide Rating

Michael D. Randall is Professor of Pharmacology, School of Life Sciences, University of Nottingham

• Preface 7Contributors 8Abbreviations 9How To Use Your Textbook 12About the Companion Website 15Part 1 Cellular Structure and Function1 Cells 16Sebastiaan Winkler2 Organisation of Cell Membranes 18Sebastiaan Winkler3 Cell Organelles 20Sebastiaan Winkler4 Protein Biochemistry 22Fergus Doherty5 Lipid Biochemistry 24Jane Arnold6 Carbohydrate Biochemistry 26Fergus Doherty7 Basic Mechanisms of Drug Action 28Michael D RandallPart 2 Cellular Metabolism8 General Principles of Cellular Metabolism 30Fergus Doherty9 Enzymes 32Michael D Randall10 Central Metabolic Pathways 34Fergus Doherty11 Fat Metabolism 36Fergus Doherty12 Glucose Metabolism 38Fergus Doherty13 Amino Acid Metabolism 40Jane ArnoldPart 3 Molecular and Medical Genetics14 Principles of Molecular Genetics 42Stuart Brown15 DNA and RNA 44Stuart Brown16 Gene Expression 46Stuart Brown17 Medical Genetics 48Stuart BrownPart 4 Nerve and Muscle18 Cell Excitability 50Michael D Randall19 Nervous Conduction 52Michael D Randall20 Synaptic Transmission 54Michael D Randall21 Autonomic Nervous System 56Michael D Randall22 Neuromuscular Transmission 58Michael D RandallPart 5 Respiratory System23 Structure of the Respiratory System 60Siobhan Loughna and Deborah Merrick24 Respiratory Physiology 62Steven Burr25 Gas Transport 64Steven Burr26 Control of Breathing 66Steven Burr27 Acid-Base Physiology 68Steven Burr28 Respiratory Pathophysiology 70Steven BurrPart 6 Cardiovascular System29 Structure of the Cardiovascular System 72Siobhan Loughna and Deborah Merrick30 Cardiac Physiology 74Michael D Randall31 Cardiovascular Physiology 76Michael D Randall32 Blood Pressure 78Michael D Randall33 Blood: 1 80Michael D Randall34 Blood: 2 82Michael D Randall35 Cardiovascular Pathophysiology 84Michael D RandallPart 7 Renal System36 Structure of the Renal System 86Deborah Merrick37 Renal Physiology: Filtration and Tubular Function 88Sue Chan38 Renal Physiology: Loop of Henle 90Sue Chan39 Regulation of Body Fluids 92Sue Chan40 Bladder Function and Dysfunction 94Michael D RandallPart 8 Digestive System41 Structure of the Gastrointestinal System 96Deborah Merrick42 Upper Gastrointestinal Physiology 98Michael D Randall43 Lower Gastrointestinal Physiology 100Michael D Randall44 The Liver 102Michael D RandallPart 9 Endocrine System45 Hypothalamus and Pituitary 104Sue Chan46 Endocrine Pancreas 106Sue Chan47 Thyroid Gland 108Sue Chan48 Adrenal Glands and Steroid Hormones 110Sue ChanPart 10 Reproductive Function49 The Genital System 112Deborah Merrick50 Reproductive Physiology 114Michael D Randall51 Human Embryology 116Deborah MerrickPart 11 Central Nervous System52 Structure of the Central Nervous System 118Deborah Merrick53 The Sensory System 120Deborah Merrick54 The Motor System 122Deborah Merrick55 Hypothalamus and Thalamus 124Deborah Merrick56 Central Nervous System Function 126Michael D Randall57 CNS Disorders and Treatments 128Michael D RandallPart 12 Infections and Immunity58 Pathogens 130James Lazenby And Chien-Yi Chang59 Recognition of Pathogens 134Lucy Fairclough and Ian Todd60 Defence Against Pathogens 136Lucy Fairclough and Ian Todd61 Integration of the Immune Response 138Lucy Fairclough and Ian Todd62 Immunopathology 140Ian Todd and Lucy Fairclough63 Immunodeficiency Disorders 142Ian Todd and Lucy FaircloughPart 13 Cancer64 Cancer 145Stuart Brown65 Chemotherapy 148Michael D RandallAppendix 1 Cross References to Medicine at a Glance (Davey) 150Index 154

Select Guide Rating