Del 121 i serien Advances in Anatomy, Embryology and Cell Biology

Human Substantia Nigra and Ventral Tegmental Area

A Neuroanatomical Study with Notes on Aging and Aging Diseases

Häftad, Engelska, 1991

AvPeter H.M.F. van Domburg,Hendrik J. ten Donkelaar,Peter H.M.F. van Domburg,Hendrik J. ten Donkelaar

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This book provides a comprehensive survey of the structure and fibre connections of the human midbrain, specifically of the substantia nigra and ventral tegmental area. The cellular and chemical architecture of these structures are analyzed and their fibre connections are discussed. The role that they play in degenerative diseases of the nervous system, such as Alzheimer's and Parkinson's diseases, is evaluated. Some functional and pathophysiological considerations are included.

Produktinformation

Utgivningsdatum1991-01-14
Mått170 x 242 x 9 mm
Vikt267 g
FormatHäftad
SpråkEngelska
SerieAdvances in Anatomy, Embryology and Cell Biology
Antal sidor132
FörlagSpringer-Verlag Berlin and Heidelberg GmbH & Co. KG
ISBN9783540528234

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1 Introduction.- 2 Materials and Techniques.- 2.1 Cytoarchitectonic Analysis.- 2.2 Quantitative Analysis.- 2.3 Immunohistochemical Procedures.- 2.4 Neuropathological Procedures.- 3 Comparative and Developmental Notes.- 3.1 The SN and VTA in Lower Tetrapods.- 3.2 The Mammalian SN and VTA.- 3.3 Development of the SN and VTA.- 4 The Human Substantia Nigra and Ventral Tegmental Area.- 4.1 Introduction.- 4.2 Cytological Features.- 4.3 Cytoarchitectonic Subdivision.- 4.4 Chemoarchitecture.- 4.5 Fiber Connections of the Primate SN Complex.- 4.6 A Model of Human Nigral Organization.- 5 Neuropathological Aspects.- 5.1 Introduction.- 5.2 Involvement of the SN and VTA in Basal Ganglia Diseases.- 5.3 Involvement of the SN and VTA in AD.- 6 Quantitative Aspects.- 6.1 Introduction.- 6.2 Age-Related Neuronal Loss.- 6.3 Neuronal Loss in the SN and VTA in AD and PD.- 7 Functional and Pathophysiological Considerations.- 7.1 Lesion Studies on the SN.- 7.2 Some Functional and Pathophysiological Aspects of Mesencephalic DAergic Projections.- 7.3 The Involvement of the SN and VTA in AD and PD.- 8 Summary.- Acknowledgements.- References.