High-Throughput Screening Assays in Toxicology

Häftad, Engelska, 2018

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This book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques.

Produktinformation

Utgivningsdatum2018-04-21
Mått178 x 254 x 10 mm
Vikt382 g
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor175
FörlagHumana Press Inc.
ISBN9781493981717

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Monitoring Ligand-Activated Protein-Protein Interactions Using Bioluminescent Resonance Energy Transfer (BRET) Assay.- Mitochondrial Membrane Potential Assay.- Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway.- Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators.- Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor Activity.- Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway.- Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells.- Determination of Histone H2AX Phosphorylation in DT40 Cells.- High-Throughput and High Content Micronucleus Assay in CHO-K1 Cells.- Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafish.- Fast Functional Germline and Epigenetic Assays in the Nematode .- A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.- Correction of Microplate Data from High-Throughput Screening.- CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprints.- Accounting Artifacts in High-Throughput Toxicity Assays.- Accessing the High-Throughput Screening Data Landscape.- Curating and Preparing High Throughput Screening Data for Quantitative Structure Activity Relationship Modeling.