High-Throughput Screening Assays in Toxicology

Inbunden, Engelska, 2022

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This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models.

Produktinformation

Utgivningsdatum2022-03-17
Mått178 x 254 x 18 mm
Vikt605 g
FormatInbunden
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor200
Upplaga2
FörlagSpringer-Verlag New York Inc.
ISBN9781071622124

Tillhör följande kategorier

Biokemisk teknik inom Naturvetenskap och teknik
Farmakologi inom Medicin

Cell-Based Assays to Identify ERR and ERR/PGC Modulators.- Mitochondrial Membrane Potential Assay.- Cell-Based hERG Inhibition Assay in a High-Throughput Format.- Identifying CAR Modulators Utilizing a Reporter Gene Assay.- Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells.- Acetylcholinesterase Inhibition Assays for High-Throughput Screening.- Cell-Based Assays to Identify Modulators of Nrf2/ARE Pathway.- Cell-Based Imaging Assay for Detection of Phospholipdosis.- GFP-LC3 High-Content Assay for Screening Autophagy Modulators.- Generation of iPSC-Derived Brain Organoids for Drug Testing and Toxicological Evaluation.- Zebrafish Behavioral Assays in Toxicology.- High Throughput Screening Assay Profiling for Large Chemical Databases.- A Quantitative High Throughput Screening Data Analysis Pipeline for Activity Profiling.- CurveP Method for Rendering High Throughput Screening Dose-Response Data into Digital Fingerprints.- Accounting for Artifacts in High Throughput Toxicity Assays.- Automatic Quantitative Structure-Activity Relationship Modeling to Fill Data Gaps in High-Throughput Screening.- Use In Silico and In Vitro Methods to Screen Hepatotoxic Chemicals and CYP450 Enzyme Inhibitors.