Glycobiology of the Nervous System

Cara-Lynne Schengrund, PhD, is Professor Emeritus, Department of Biochemistry and Molecular Biology, Penn State University, Hershey, PennsylvaniaRobert K. Yu, PhD, Med ScD, is Professor, Department of Neuroscience and Regenerative Medicine, and GRA Eminent Scholar in Molecular and Cellular Neurobiology, Medical College of Georgia at Augusta University, Augusta, Georgia

• 1 Introduction to the Complexity of Cell Surface and Tissue Matrix GlycoconjugatesVeer P. Bhavanandan, D. Channe Gowda2 Introduction to Cells Comprising the Nervous SystemDouglas G. Peters, James R. Connor3 Synthesis, Processing, and Function of N-glycans in N-glycoproteinsErhard Bieberich4 Synthesis of O-linked Glycoconjugates in the Nervous SystemJin-Ichi Inokuchi, Shinji Go, Yoshio Hirabayashi5 Chemistry and Function of Glycosaminoglycans in the Nervous SystemNancy B. Schwartz, Miriam S. Domowicz6 Use of Glycan-targeted Antibodies/Lectins to Study the Expression/Function of Glycosyltransferases in the Nervous SystemYasuhiko Kizuka, Kenji Kanekiyo, Shinobu Kitazume, Naoyuki Taniguchi7 From Mass Spectrometry-based Glycosylation Analysis to Glycomics and GlycoproteomicKay-Hooi Khoo8 Structural Analysis of Oligosaccharides and Glycoconjugates using NMRYoshiki Yamaguchi, Takumi Yamaguchi, Koichi Kato9 Glycolipid and Glycoprotein Expression During Neural DevelopmentRobert K. Yu, Yutaka Itokazu10 Gangliosides and Cell Surface Ganglioside Glycohydrolases in the Nervous SystemMassimo Aureli, Maura Samarani, Valentina Murdica, Laura Mauri, Nicoletta Loberto, Rosaria Bassi, Alessandro Prinetti, Sandro Sonnino11 Role of Myelin-Associated Glycoprotein (Siglec-4a) in the Nervous SystemPablo H.H. Lopez12 Role of Galactosylceramide and Sulfatide in Oligodendrocytes and CNS Myelin: Formation of a GlycosynapseJoan M. Boggs13 Glycosignaling – A General ReviewGlyn Dawson14 Glycosphingolipids in the Regulation of the Nervous SystemKoichi Furukawa, Yusuke Ohmi, Yuki Ohkawa, Orie Tajima, Keiko Furukawa15 Glycobiology of Ion Transport in the Nervous SystemMartha C. Nowycky, Gusheng Wu, Robert W. Ledeen16 O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in NeurodegenerationOlof Lagerlöf, Gerald W. Hart17 N-glycosylation in Regulation of the Nervous SystemHilary Scott, Vladislav M. Panin18 Roles of Carbohydrates in the Interaction of Pathogens with Neural CellsCara-Lynne Schengrund19 Glycoconjugate Changes in Aging and Age-related DiseasesSusumu Ando20 Gangliosides and Glycolipids in Neurodegenerative DisordersJ. S. Schneider21 Glycosidases: Inborn Errors of Glycosphingolipid CatabolismHisashi Ashida, Yu-Teh Li22 Ganglioside Storage Diseases: On the Road to ManagementThomas N. Seyfried, Hannah E. Rockwell, Karie A. Heinecke, Douglas R. Martin, Miguel Sena-Esteves23 Dynamic Aspects of Neural Tumor GangliosidesStephan Ladisch, Yihui Liu24 Galectins and NeuroinflammationHung-Lin Chen, Fang Liao, Teng-Nan Lin, Fu-Tong Liu25 Glycoconjugates and Neuroimmunological DiseasesHugh J. Willison