Del 35 - Translational Epigenetics

Chromatin Readers in Health and Disease

Häftad, Engelska, 2023

Av Olivier Binda, UK) Binda, Olivier (Principal Investigator, Newcastle Cancer Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, Trygve O. Tollefsbol, Trygve O Tollefsbol

2 209 kr

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Chromatin Readers in Health and Disease, Volume 35, a new release in the Translational Epigenetics series, gathers and makes actionable our current understanding of how chromatin readers regulate access to genetic information, and how their aberrant regulation can contribute to human pathologies. Chromatin readers discussed include 14-3-3 Dinshaw, ADD, Ankyrin, BAH, BET, BIR, BRCT, bromodomains and Kac readers, chromodomains and chromobarrel readers, citrullination readers, macrodomains and poly-ADP-ribose readers, MBT, PHD and double PHD, PWWP, SUMO (H4K12) readers, Tudor and TTD, UDR and ubiquitin, WD40, YEATS (crotonyl reader), MBD, SRA, and Methyl-RNA readers.

In the book, more than a dozen leaders in the field examine a range of protein readers, their relationship to human disease, and the early therapeutics that act as chromatin signaling factors to treat cancers and Huntington's disease, among other disorders.

Enables researchers and clinicians to understand chromatin signaling mechanisms that regulate gene expression through chromatin readers
Highlights the role of chromatin readers in a variety of human pathologies, as well as early therapeutics that act on chromatin signaling
Includes chapter contributions from international leaders in the field

Produktinformation

Utgivningsdatum2023-09-22
Mått191 x 235 x 24 mm
Vikt450 g
SpråkEngelska
SerieTranslational Epigenetics
Antal sidor420
FörlagElsevier Science
EAN9780128233764

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Biovetenskap inom Naturvetenskap och teknik

Dr. Olivier Binda is a Researcher at the University of Ottawa, specializing in epigenetics and gene expression as it relates to human diseases. Dr. Binda co-edited Chromatin Signaling and Diseases (Elsevier 2016), a volume in Elsevier’s Translational Epigenetics series, and has published 20 scientific papers in such peer reviewed journals as the Molecular Cell, Journal of Biological Chemistry, Biochemistry, Epigenetics, Oncogene, Scientific Reports, and Stem Cell Research. In past positions he has served as a postdoctoral fellow at McGill University and Stanford University, and he completed his PhD in Biochemistry at McGill University in 2007.Affiliations and expertiseUniversity of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, CANADA.Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

1. ADD domains – a regulatory hub in chromatin biology and disease2. BAH3. BIR4. BRCT Domains as Chromatin Readers: Structure, Function, and Clinical Implications5. The bromodomain acyl-lysine readers in human health and disease6. Chromodomains7. CW-type zinc fingers8. Macrodomains and PAR readers9. MBT10. PHD and double PHD finger11. PWWP12. SPIN repeats and human pathologies13. Tudor and TTD14. UDR and Ubiquitin15. WD4016. YEATS17. Multivalent readers and interplay among different readers18. DNA Methylation and Reader- or Writer-Proteins: Differentiation and Disease19. R-loops readers20. CUT&RUN and CUT&Tag: Low-input methods for genome-wide mapping of chromatin proteins