Cerebrospinal Fluid and Subarachnoid Space

R. Shane Tubbs, MS, PA-C, PhD is a native of Birmingham, Alabama, USA and a is a clinical anatomist, author, editor, educator, and researcher. He is Professor of Neurosurgery, Neurology, Surgery, and Structural & Cellular Biology, Director of Surgical Anatomy at Tulane School of Medicine and Program Director of Anatomical Research in the Clinical Neuroscience Research Center at Tulane University School of Medicine, New Orleans, Louisiana and Department of Neurosurgery and Ochsner Neuroscience Institute Ochsner Health System, New Orleans, LA. He has multiple honorary professorships/faculty positions both in the US and abroad. Dr. Tubbs is President-elect of the American Association of Clinical Anatomists (AACA) and serves as its Journal’s (Clinical Anatomy) Editor-in-Chief. Dr. Tubbs’ research interests are centered around what has been termed “reverse translational anatomy research” where clinical/surgical problems are identified and solved/explained with anatomical studies. This investigative paradigm in anatomy has resulted in over 1,800 peer reviewed publications from his laboratory. Dr. Tubbs’ laboratory has made novel discoveries in human anatomy and in 2018, he was listed as a “hyperprolific author” in the journal Nature. Dr. Tubbs sits on the editorial board of over 10 anatomical journals and over 30 clinical journals and has reviewed for over 150 various scientific journals. He has authored/edited over 50 books and over 80 book chapters primarily in anatomical and neurosurgical textbooks. Lastly, Dr. Tubbs is Chair of the Federative International Programme on Anatomical Terminologies (FIPAT) and oversees six working groups dedicated to this topic. Under his leadership, the second edition of Terminologia Anatomica was just published. Joe Iwanaga, DDS, PhD, is a clinical anatomist and an oral and maxillofacial surgeon. He is the author of more than 400 articles in peer-reviewed journals. Dr. Iwanaga is a Councilor-at-Large of the American Association of Clinical Anatomists, and Coordinator of the FIPAT Oral Anatomy Working Group of the International Federation of Associations of Anatomists. He is a Dental, Oral and Maxillofacial Section editor of the journal Clinical Anatomy. Dr. Rizk is a neurosurgeon at the Penn State Hershey Medical Center with a clinical specialty in pediatric peripheral nerve surgery. He has multiple publications on the PNS and is active in basic science research regarding peripheral nerve regeneration. Anthony V. D'Antoni works in the Department of Radiology at Weill Cornell Medicine, New York, NY, USA. Dr. Aaron S. Dumont serves as the Director of The Tulane Center for Clinical Neurosciences as well as the Charles B. Wilson Professor and Chair of the Department of Neurosurgery at Tulane University School of Medicine. He is board-certified in neurosurgery and neurocritical care. Dr. Dumont completed his residency at the University of Virginia as well as a fellowship in cerebrovascular, skull base, and endovascular neurosurgery at the University of Virginia. He has interests in all areas of pediatric and adult neurosurgery including spine disorders, movement disorders, epilepsy, stroke, and cerebrovascular disease, peripheral nerve disease, radiosurgery, and tumors of the brain and spine. He is dually trained in open traditional microsurgery and minimally invasive endovascular surgery for vascular disorders of the brain and spine. He has active neurosurgical research interests and has published and presented extensively with more than 200 publications and more than 175 national and international presentations. He is a member of the Editorial Board of the Journal of Neurosurgery (the specialty’s leading scientific journal) and serves on the Editorial Boards of several other academic journals.

• 1. Historical perspectives2. Development of the ventricles, choroid plexus and subarachnoid space3. Anatomy of the ventricles and subarachnoid spaces and cisterns4. Anatomy of choroid plexus, capillary endothelial cells, ependymal layer, pia and arachnoid granulations/villi, extracellular space5. Spinal punctures6. CSF in the animal kingdom7. Animal models for CSF testing8. CSF physiology: Production, circulation, absorption, function, extrachoroidal formation/absorption9. CSF and basal lymphatic system in mammals10. A new look at CSF circulation11. Virchow Robin spaces12. CSF and disposition of alpha synuclein13. CSF in pediatrics: prematurity, neonates, infants, and toddlers 14. CSF imaging15. CSF in neurodegenerative disease processes16. CSF in trauma17. CSF in pregnancy18. CSF in space, high-altitude or deep sea diving19. CSF fluid replacement20. Glymphatic system and CSF21. Lymphatic system and CSF22. Blood brain barrier23. Intracranial/intraspinal pressure24. Intracranial pressure (ICP) in trauma and autoregulation25. ICP in slit ventricle syndrome26. ICP and over drainage27. Non invasive ICP monitoring28. NPH29. ICP in normal pressure hydrocephalus (NPH)30. Neuropsychological testing and NPH31. Shunt infections32. Shunt complications33. Drugs and CSF production and ICP34. Hydrocephalus treatment “historical perspective”35. Hydrocephalus and shunt valves36. Reasons for shunting and revision surgery: UK registry data37. Infections of CSF38. CSF and disease:39. CSF and headaches40. CSF markers and exosomes41. CSF in Chiari I malformation42. CSF in Chiari II malformation43. Neurophysiological consequences of hydrocephalus44. Hemorrhage and hydrocephalus45. Arrested hydrocephalus46. Aqueductal stenosis47. Hydrocephalus and genetic disorders48. Biomarkers of hydrocephalus49. Long-term prognosis of fetal hydrocephalus50. Circumventricular organs51. Endoscopic third ventriculostomy and choroid plexus coagulation52. Failure of ETV53. Learning disabilities in hydrocephalus54. Hydrocephalus in craniosynostosis55. Syringomyelia56. Arachnoid cysts57. Neuro endoscopic anatomy58. Endoscopy technique59. Hydrocephalus in the developing world60. Economics of hydrocephalus61. Hydrocephalus and Fetal surgery for myelomeningocele62. Ventricular anatomy in Chiari II malformation63.Venous outflow obstruction and hydrocephalus64. CSF markers before and after shunting65. Spinal CSF compartments66. Ventricular access devices in neonatal hemorrhage67. Body position and lumbar CSF leak68. Spontaneous CSF leak69. Visual pathway and hydrocephalus70. Effect of decompressive craniectomy on CSF pulsatility71. Direct control of CSF pulsatility and its effect on cerebral blood Flow72. The pulsating brain73. Choroid plexus transport74. Amyloid, tau, alpha synuclein and CSF dynamics