Cellular and Molecular Biology of Nitric Oxide

Jeffrey D. Laskin, Debra L. Laskin

• Transcriptional regulation of the genes encoding nitric oxide synthase; arginine synthesis, metabolism, and transport - regulators of nitric oxide synthesis; inactivation of nitric oxide synthase isoforms by metalloporphyrins; nitric oxide, peroxynitrite, and carbon monoxide poisoning; structure-activity relationships in NOS inhibitors; homeostatic and pathological actions of nitric oxide in the kidney; roles of protein kinase C in the synthesis and cellular action of nitric oxide; nitric oxide and inflammation in autoimmune disorders; protective and pathologic roles of nitric oxide in tissue injury; nitric oxide and cell death in inflammation; nitric oxide as a cellular mediator of apoptosis; nitric oxide biosynthesis and metabolism in keratinocytes - the functions and consequences of nitric oxide production in the skin; taurine chloramine, an inhibitor of iNOS expression and a potential modulator of inflammation; modulation of the nitric oxide pathway by natural products; the role of DNA synthesis and cytokine-generated oxidants in hepatocyte necrosis and apoptosis.

". . .a comprehensive and up-to-date review of the current state of [nitric oxide biology, biochemistry and toxicology]. "---Acta Cardiologica". . .a useful and readable book. "---Free Radical Research"The book is very well written and even complex pieces of information are presented in an easy-to-read way.. . .recommend[ed] to all researchers and clinicians, from experienced scientists and medical practitioners to medical and biology students, and all other specialists interested in nitric oxide and its stunningly varied and multiple effects on the organisms. Folia Microbiologica ...Cellular and Molecular Biology of Nitric Oxide is a fascinating tool that helps us to not lose reference to cellular mechanisms of endogenous and exogenous NO in clinical use. I learned a lot."---Respiratory Care