Carcinogenicity of Metals

40 years research into the biology and pathology of the skin and its response to injury. Research into the nutrition and physiology of trace and xenbiotic metals in the skin. Study of intrinsic cytoprotective mechanisms against metal toxicity. Special studies onthe biological value of silver in wound care and as an antimicrobial agent in medical devices. International consultant and lecturer. Published 250 scientific papers and book chapters.

• Introduction;Criteria and Classification of Metals and Metalloid Elements as Carcinogens;Interaction between elements in carcinogenesis;Arsenic, antimony and bismuth;Chromium, nickel, cobalt, tungsten and the hard metal complexes;Beryllium;Aluminium and zirconium;Zinc, cadmium and mercury;Lead;Iron;Precious metals, Silver, Gold and Platinum-related metals;Miscellaneous metals and metalloid elements;Mechanisms and modes of action in metal-related carcinogenesis;Discussion and Conclusions

"This book is 18th in a series on issues in toxicology. It is an excellent review of information relating to the potential carci- nogenicity of 27 metals and metalloid elements based on var- ious degrees of evidence from occupational, environmental, animals, and in vitro studies. The author does more than report the results; he evaluates the quality, relevance of the studies, and weight of the evidence of all the relevant data. For each metal, other useful information about natural occurrence, diet- ary levels, toxicity, and so on is listed.""The possible mechanism of carcinogenesis is complex and the author does a good job of summarizing how genetic and epigenetic mechanisms are operational for the various metals.""This book provides an excellent review of metal toxicity and occupational and environmental exposures related to mining and use of metals and would be useful in graduate courses in occupational medicine, toxicology, and carcinogenicity. It would also be a very useful resource to occupational physi- cians, toxicologists, industrial hygienists, environmental, and product safety specialists interested in metal carcinogenicity and occupational and environmental exposure to metals. This book is well written by an individual with an excellent knowl- edge of metal carcinogenicity and related occupational and environmental exposure."