Arsenic

J. Christopher States, PhD, is Professor, University Scholar and Vice Chair for Graduate Education  in the Department of Pharmacology and Toxicology, and Associate Dean for Research in the University of Louisville School of Medicine, Louisville, Kentucky. He is a Past President of the Society of Toxicology Metals Specialty Section, on the editorial board of several leading journals, and regularly serves as a reviewer of manuscripts and National Institutes of Health grants. He has organized symposia and workshops and chaired sessions on arsenic exposure and toxicology at international conferences and published over 100 articles.

• Contributors ixPreface xiiiPart I Fundamentals of Arsenic Exposure and Metabolism 11 History of Arsenic as a Poison and a Medicinal Agent 3Michael F. Hughes2 Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils: Distribution, Nature, Origin, and Human Exposure Routes 23David A. Polya and Michael Lawson3 Remediation of Arsenic in Drinking Water 61Cathleen J. Webb and Arden D. Davis4 The Chemistry and Metabolism of Arsenic 81David J. ThomasPart II Epidemiology and Disease Manifestations of Arsenic Exposure 1115 Human Population Studies and Nutritional Intervention 113Yu Chen and Fen Wu6 Skin Manifestations of Chronic Arsenicosis 127Nilendu Sarma7 Lung Cancer and Other Pulmonary Diseases 137Cara L. Sherwood and R. Clark Lantz8 Bladder Cancer and Arsenic 163Matthew K. Medeiros and A. Jay Gandolfi9 Neurological Effects of Arsenic Exposure 193Dominic B. Fee10 Diabetes Mellitus 221Miroslav Styblo and Christelle Douillet11 Hepatotoxicity 249Gavin E. Arteel12 Genetic Epidemiology of Susceptibility to Arsenic‐Induced Diseases 267Mayukh Banerjee and Ashok K. GiriPart III Mechanisms of Toxicity 28913 Arsenic Interaction with Zinc Finger Motifs 291Laurie G. Hudson, Karen L. Cooper, Susan R. Atlas, Brenee S. King and Ke Jian Liu14 Role in Chemotherapy 315Koren K. Mann and Maryse Lemaire15 Genotoxicity 347Ana Maria Salazar and Patricia Ostrosky‐Wegman16 Arsenic and Signal Transduction 369Ingrid L. Druwe and Richard R. Vaillancourt17 Stem Cell Targeting and Alteration by Arsenic 397Yuanyuan Xu, Erik J. Tokar and Michael P. Waalkes18 Epigenetics and Arsenic Toxicity 421Somnath Paul and Pritha BhattacharjeePart IV Models for Arsenic Toxicology and Risk Assessment 43919 Cancer Induced by Exposure to Arsenicals in Animals 441Erik J. Tokar, Yuanyuan Xu and Michael P. Waalkes20 Arsenic‐Induced Cardiovascular Disease 453Aaron Barchowsky and J. Christopher States21 Invertebrate Models in Arsenic Research: Past, Present, and Future 469Iain L. Cartwright22 Toxicokinetics and Pharmacokinetic Modeling of Arsenic 495Elaina M. Kenyon and Harvey J. Clewell, III23 Considerations for a Biologically Based Risk Assessment for Arsenic 511Harvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager24 Translating Experimental Data to Human Populations 535J. Christopher StatesIndex 549