Understanding the Gut-Bone Signaling Axis

Mechanisms and Therapeutic Implications

Häftad, Engelska, 2018

Av Laura R. McCabe, Narayanan Parameswaran

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This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases.

Produktinformation

Utgivningsdatum2018-09-09
Mått155 x 235 x 16 mm
Vikt446 g
FormatHäftad
SpråkEngelska
SerieAdvances in Experimental Medicine and Biology
Antal sidor277
FörlagSpringer International Publishing AG
ISBN9783319882932

Tillhör följande kategorier

Biovetenskap inom Naturvetenskap och teknik
Endokrinologi inom Medicin
Fysiologi inom Medicin

Laura R. McCabe, PhD is the Director of the Molecular Metabolism and Disease Program at Michigan State University. Dr. McCabe’s research focuses on understanding the mechanisms regulating bone cell (osteoblast) differentiation and bone formation. Her lab is taking an integrative approach to examine bone adaptation to diseases (such as diabetes and inflammatory bowel disease) and is working toward identifying mechanisms regulating bone formation by osteoblasts. Approaches include examination of transcription factor activity, intracellular signaling pathway activation, stem cell lineage selection, apoptosis, metabolism and immune system contributions utilizing cell culture systems, animal models and human imaging. Dr. McCabe’s lab is also developing therapeutics to target identified mechanisms and pathways to increase bone formation.

Section I: Gut and Bone Physiology.- 1.Introduction.- 2.GI Research: Physiology and Gut Signaling to other organs.- Section II: Gut-Bone Signaling Pathways.- 3. Intestinal regulation of Calcium-Vitamin D and Regulation of Bone Physiology.- 4. GI Regulation of Incretins and Modulation of Bone.- 5.Intestinal Serotonin Regulation of Bone Physiology.- 5. Gut Microbiome and Bone Physiology.- 6. Intestinal Immune System and Regulation of Bone.- Section III: Gut Pathologies Affecting Bone Health.- 7. Stomach-Bone: Gastric Acid and Calcium Absorption.- 8. Inflammatory Bowel Disease: Human IBD and Mouse IBD Models.- 9. Antibiotic Use.- 10. Enteritis and Pathogens: Dysbiosis, Pediatrics and Aging.- 11. Enteritis and Pathogens: Chicken Models.- Section IV: Modulation of the Gut Microbiota to Support Bone Health.- 12. Prebiotics.- 13.- Probiotics.- 14. Germ Free Applications.