The expanding field of nanotechnology is now one of the most promising areas of science. However, because some nanoparticles can have a negative impact on human health and the environment, the design of novel materials must always be accompanied by a comprehensive risk assessment. Until now, the information on the methods available has been fragmented and incomplete. This book is the first to provide a comprehensive review of recent progress and challenges in the risk assessment of nanomaterials by empirical and computational techniques. Topics covered include: benefits versus risks, carbon based nanomaterials, environmental detection and quantitative analysis, chemometric modelling, human exposure assessment, toxicity testing, nano-QSAR, risk assessment strategies, policy and regulatory frameworks.
Jerzy Leszczynski is Professor of Chemistry and a President's Distinguished Fellow. Director of Interdisciplinary Nanotoxicity Center. Author and co-author of almost 700 peer-reviewed papers (H index 47) and 50 book chapters.
Nanomaterials: benefits and risks;Experimental characterizing structural properties of nanoparticles related to their toxicity;Structure-property mapping methods;Modelling properties of nanoparticles based on quantum-mechanical methods;Ontology;Empirical determination of nanoparticles' behavior in environmental media;Computational mass-ballance modeling of environmental transport and fate of engineered nanoparticles;Pharmacokinetics and biological fate of nanoparticles;Pharmacokinetic-based modeling;Modeling kinetics of nanoparticle cellular interaction and transport;Toxicity and Ecotoxicity testing of engineered nanoparticles - experimental point of view;In vitro toxicity of nanomaterials;In vivo testing;Computational modeling of interactions between nanoparticles and other species;Comprehensive Environmental Assessment as a Tool for Nanomaterial Risk Assessment;Predicting oxidative stress;Nano-QSAR