The Zebrafish Model of Neurodegenerative Disorders

Knowing the Unknown

Häftad, Engelska, 2027

2 639 kr

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The Zebrafish Model of Neurodegenerative Disorders: Knowing the Unknown reveals a ground-breaking method for decoding neurodegenerative disorders such as Parkinson's, Alzheimer's, ALS, and Huntington's through the lens of the zebrafish. This volume bridges the divide between fundamental science and clinical innovation, demonstrating how the genetic malleability, transparent embryos, and conserved neural pathways of zebrafish provide unparalleled insights into neurodegeneration. It illustrates the potential to uncover concealed pathological mechanisms, expedite drug discovery, and surmount the translational failings that impede current research using this gold-standard model species. Featuring contributions from global experts, this volume is systematically structured into five topical sections for ease of navigation. These sections explore the role of cutting-edge tools such as CRISPR-Cas9, AI-driven phenotyping, and high-throughput drug screening in the study of ?-synuclein aggregation in Parkinson's Disease and amyloid-? toxicity in Alzheimer's Disease. The volume offers real-world applications, comparative analyses of zebrafish and mammalian models, and actionable protocols that translate zebrafish discoveries to clinical trials. The Zebrafish Model of Neurodegenerative Disorders is designed to empower researchers, clinicians, and healthcare professionals by addressing existing gaps in knowledge, particularly fragmentation in protocols and the translational disconnect between preclinical models and human trials. By fostering an integrated understanding of zebrafish as a model for neurodegeneration, it enhances research reproducibility, accelerates drug discovery, and promotes ethical, scalable research practices. Whether used as a teaching resource or a reference for experimental design, this volume offers invaluable insights to advance the understanding and treatment of devastating neurodegenerative diseases.

Includes chapters on shared and unique pathways for Parkinson’s, Alzheimer’s, ALS, and Huntington’s
Provides standardized protocols for disease modeling and drug screening
Highlights translational pathways from zebrafish data to clinical applications
Showcases innovative tools like AI-driven phenotyping and omics approaches
Facilitates cross-disciplinary research with comprehensive comparative analyses

Produktinformation

Utgivningsdatum2027-04-01
Mått152 x 229 x undefined mm
Vikt450 g
FormatHäftad
SpråkEngelska
Antal sidor400
FörlagElsevier Science
ISBN9780443457098

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Section I. Neurodegeneration – Pathophysiology and Unmet Needs1. The global burden of neurodegenerative disorders: From Alzheimer’s to ALS2. Limitations of current models: Why zebrafish? .3. Emerging biomarkers and diagnostic challengesSection II. Zebrafish Biology and Methodological Innovations4. Zebrafish neuroanatomy: A window into conserved and divergent pathways5. Genetic tools: CRISPR, transgenics, and disease variants6. High-throughput screening and AI-driven phenotypingSection III. Modelling Specific Neurodegenerative Disorders7. Parkinson’s Disease: From α-synuclein to dopaminergic circuitry8. Toxin-induced PD models: MPTP, 6-OHDA, and rotenone protocols9. Alzheimer’s Disease: Amyloid-β, tau, and cognitive decline10. Huntington’s Disease: Tracking PolyQ aggregation in real time11. ALS and motor neuron degeneration: Lessons from zebrafish12. Cognitive decline using zebrafish modelSection IV. Uncharted Territories and Translational Insights13. The gut-brain axis: Zebrafish insights into microbiome interactions14. Non-motor symptoms: Sleep, anxiety, and metabolic dysregulation15. From bench to bedside: Case studies in drug repurposing16. Mitochondrial dysfunction and the PINK1-Parkin pathway in zebrafish17. Neuroinflammation in PD: Microglial activation and cytokine profiling18. Neuronal differentiation in zebrafish embryoSection V. Translational Applications and Innovations19. Biomarker discover: Omics approaches in zebrafish Parkinson’s Disease models20. Stem cell therapy: Dopaminergic neuron regeneration in zebrafish21. AI-driven behavioral analysis: Quantifying motor and cognitive decline22. From zebrafish to clinic: Case studies in LRRK2 inhibitor development23. Behavioral assessment in zebrafish24. Bridging the gap: Practical steps to adopting zebrafish models in neurodegeneration studiesSection VI. Comparative and Ethical Perspectives25. Zebrafish versus mammalian models: Strengths, limitations, and synergies26. Ethical challenges in zebrafish research: Balancing innovation and welfare