Synthesis and Biological Evaluation of Mast Cell Stabilizers

The role of mast cells can be protective or harmful: depending upon the physiological/pathological condition in which they get activated. The latter role is due to mast cell degranulation and the release of an array of incendiary mediators. Mast cells have a well-established role in diseases like allergy, eczema, anaphylactic shock, mastocytosis, and other miscellaneous mast cell disorders. The derivatives of spiro--carboline were evaluated for mast cell stabilization activity by compound 48/80 induced degranulation histamine release assay. The mast cell stabilization of 2-Heptyl-2,3,4,9-tetrahydrospiro[cyclohexane-1,1-pyrido[3,4-b]indole]-3-carboxylic acid (IC50 = 0.389 0.015 M) and 2-Benzoyl 2,3,4,9-tetrahydrospiro[cyclohexane-1,1-pyrido[3,4-b]indole]-3-carboxylic acid (IC50 = 00.469 0.032 M) compounds were to be of similar potency as that of standard drug sodium cromoglycate (IC50 =0.489 0.003M).