Rodent Models of Stroke

• From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling.- How to Avoid Bumping into the Translational Roadblock.- Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview.- Focal Cerebral Ischemia in the Mouse and Rat Using the Intraluminal Suture–Filament Model.- Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding Devices, and Endothelin-1.- Rodent Models of Thromboembolic Stroke.- Photochemical and Endothelin Models of Focal Brain Ischemia.- Housing in an Enriched Environment: A Tool to Study Functional Recovery After Experimental Stroke.- Modeling Risk Factors and Confounding Effects in Stroke.- Effect of Anesthesia in Stroke Models.- Noninvasive Brain Imaging in Small Animal Stroke Models: MRI and PET.- Non-invasive Optical Imaging in Small Animal Models of Stroke.- Behavioral Testing in Mouse Models of Stroke.- Behavioral Testing in Rodent Models of Stroke.- Histology and Infarct Volume Determination.- Ethics of Modeling of Cerebral Ischemia in Small Animals.- Quality Control and Standard Operating Procedures.- Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing.- Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers.

From the reviews:“Rodent Models of Stroke by U. Dirnagl is simply the best ischemia book on principles, theory, protocols, and techniques which has been written over the past 25 years. … This book is aimed at a broad audience on ischemia research including graduate students, postgraduate scholars, junior faculty, and senior seasoned investigators. … In short, this is an ideal textbook for being a primer or a detailed reference to refer to. I highly recommend it.” (Joseph J. Grenier, Amazon.com, September, 2013)